Head Coach: Scott Luster Record: 10-23
| Date | Site | Opponent | W/L | UL | Opp | Overall | City | Event | Type |
|---|---|---|---|---|---|---|---|---|---|
| 09/13/1980 | H | Mount St. Joseph | L | 1 | 2 | 0-1 | Louisville, Ky. | ||
| 09/13/1980 | H | Dayton | L | 1 | 2 | 0-2 | Louisville, Ky. | ||
| 09/13/1980 | H | Kentucky | L | 0 | 2 | 0-3 | Louisville, Ky. | ||
| 09/16/1980 | A | Northern Kentucky | L | 1 | 3 | 0-4 | Highland Heights, Ky. | ||
| 09/18/1980 | N | Midway | W | 2 | 0 | 1-4 | Louisville, Ky. | ||
| 09/18/1980 | A | Bellarmine | W | 2 | 1 | 2-4 | Louisville, Ky. | ||
| 09/20/1980 | N | Kent State | L | 1 | 3 | 2-5 | Muncie, Ind. | ||
| 09/20/1980 | A | Ball State | L | 1 | 3 | 2-6 | Muncie, Ind. | ||
| 09/23/1980 | A | Kentucky | L | 0 | 3 | 2-7 | Lexington, Ky. | ||
| 09/26/1980 | A | Memphis | L | 1 | 2 | 2-8 | Memphis, Tenn. | Metro Conference Tournament | CT |
| 09/26/1980 | N | Florida State | L | 0 | 2 | 2-9 | Memphis, Tenn. | Metro Conference Tournament | CT |
| 09/26/1980 | N | Saint Louis | L | 1 | 2 | 2-10 | Memphis, Tenn. | Metro Conference Tournament | CT |
| 09/27/1980 | N | Cincinnati | W | 2 | 0 | 3-10 | Memphis, Tenn. | Metro Conference Tournament | CT |
| 09/27/1980 | N | Tulane | W | 2 | 0 | 4-10 | Memphis, Tenn. | Metro Conference Tournament | CT |
| 09/27/1980 | N | Virginia Tech | W | 2 | 0 | 5-10 | Memphis, Tenn. | Metro Conference Tournament | CT |
| 09/30/1980 | H | Morehead State | W | 3 | 1 | 6-10 | Louisville, Ky. | ||
| 10/03/1980 | A | Ohio | L | 1 | 2 | 6-11 | Athens, Ohio | ||
| 10/03/1980 | N | Temple | L | 1 | 2 | 6-12 | Athens, Ohio | ||
| 10/04/1980 | N | Cleveland State | L | 0 | 2 | 6-13 | Athens, Ohio | ||
| 10/07/1980 | A | Eastern Kentucky | L | 1 | 3 | 6-14 | Richmond, Ky. | ||
| 10/14/1980 | A | Morehead State | L | 0 | 3 | 6-15 | Morehead, Ky. | ||
| 10/17/1980 | N | Marshall | L | 0 | 2 | 6-16 | Dayton, Ohio | ||
| 10/18/1980 | N | Saint Louis | L | 1 | 2 | 6-17 | Dayton, Ohio | ||
| 10/18/1980 | A | Wright State | L | 0 | 2 | 6-18 | Dayton, Ohio | ||
| 10/18/1980 | N | Indiana State | W | 2 | 0 | 7-18 | Dayton, Ohio | ||
| 10/21/1980 | H | Northern Kentucky | L | 1 | 3 | 7-19 | Louisville, Ky. | ||
| 10/25/1980 | A | Indiana State | L | 2 | 3 | 7-20 | Terre Haute, Ind. | ||
| 10/25/1980 | N | Western Illinois | L | 0 | 3 | 7-21 | Terre Haute, Ind. | ||
| 10/28/1980 | H | Eastern Kentucky | L | 2 | 3 | 7-22 | Louisville, Ky. | ||
| 10/30/1980 | A | Kentucky State | W | 3 | 0 | 8-22 | Frankfort, Ky. | ||
| 11/08/1980 | H | Tennessee Tech | W | 2 | 1 | 9-22 | Louisville, Ky. | ||
| 11/08/1980 | H | Indiana State | L | 1 | 2 | 9-23 | Louisville, Ky. | ||
| 11/08/1980 | H | Bellarmine | W | 2 | 1 | 10-23 | Louisville, Ky. |