Head Coach: Scott Luster Record: 26-18
| Date | Site | Opponent | W/L | UL | Opp | Overall | City |
|---|---|---|---|---|---|---|---|
| 09/08/1981 | H | Eastern Kentucky | L | 0 | 3 | 0-1 | Louisville, Ky. |
| 09/10/1981 | A | Mount St. Joseph | W | 3 | 1 | 1-1 | Cincinnati, Ohio |
| 09/12/1981 | A | Dayton | L | 2 | 3 | 1-2 | Dayton, Ohio |
| 09/14/1981 | H | Morehead State | L | 2 | 3 | 1-3 | Louisville, Ky. |
| 09/17/1981 | A | Southern Illinois | L | 1 | 3 | 1-4 | Carbondale, Ill. |
| 09/18/1981 | N | Memphis | L | 0 | 3 | 1-5 | Springfield, Mo. |
| 09/19/1981 | A | Southwest Missouri State | L | 2 | 3 | 1-6 | Springfield, Mo. |
| 09/19/1981 | N | Oral Roberts | L | 0 | 3 | 1-7 | Springfield, Mo. |
| 09/23/1981 | H | Bellarmine | W | 3 | 0 | 2-7 | Louisville, Ky. |
| 09/25/1981 | N | Pittsburgh | W | 2 | 1 | 3-7 | Cincinnati, Ohio |
| 09/25/1981 | A | Cincinnati | L | 0 | 2 | 3-8 | Cincinnati, Ohio |
| 09/25/1981 | N | Ohio State | L | 0 | 2 | 3-9 | Cincinnati, Ohio |
| 09/25/1981 | N | Xavier | W | 2 | 1 | 4-9 | Cincinnati, Ohio |
| 09/26/1981 | N | Marshall | W | 2 | 1 | 5-9 | Cincinnati, Ohio |
| 09/26/1981 | N | Illinois-Chicago | W | 2 | 1 | 6-9 | Cincinnati, Ohio |
| 09/29/1981 | A | Northern Kentucky | W | 3 | 1 | 7-9 | Highland Heights, Ky. |
| 10/02/1981 | N | Princeton | L | 1 | 2 | 7-10 | Morgantown, W.Va. |
| 10/02/1981 | A | West Virginia | W | 2 | 1 | 8-10 | Morgantown, W.Va. |
| 10/02/1981 | N | Kent State | L | 1 | 2 | 8-11 | Morgantown, W.Va. |
| 10/03/1981 | N | Maryland | W | 2 | 0 | 9-11 | Morgantown, W.Va. |
| 10/03/1981 | N | Cincinnati | W | 2 | 1 | 10-11 | Morgantown, W.Va. |
| 10/03/1981 | N | Cincinnati | L | 0 | 2 | 10-12 | Morgantown, W.Va. |
| 10/06/1981 | H | Indiana | W | 3 | 2 | 11-12 | Louisville, Ky. |
| 10/08/1981 | H | Georgetown, Ky. | W | 3 | 2 | 12-12 | Louisville, Ky. |
| 10/09/1981 | N | Pittsburgh | L | 0 | 3 | 12-13 | Columbus, Ohio |
| 10/10/1981 | A | Ohio State | L | 0 | 3 | 12-14 | Columbus, Ohio |
| 10/13/1981 | A | Indiana State | W | 3 | 2 | 13-14 | Terre Haute, Ind. |
| 10/16/1981 | A | Eastern Kentucky | W | 3 | 0 | 14-14 | Richmond, Ky. |
| 10/17/1981 | N | Tennessee-Martin | W | 2 | 0 | 15-14 | Cookeville, Tenn. |
| 10/17/1981 | N | Middle Tennessee | W | 2 | 0 | 16-14 | Cookeville, Tenn. |
| 10/17/1981 | A | Tennessee Tech | W | 2 | 0 | 17-14 | Cookeville, Tenn. |
| 10/21/1981 | H | Evansville | W | 3 | 0 | 18-14 | Louisville, Ky. |
| 10/21/1981 | H | Mount St. Joseph | W | 3 | 0 | 19-14 | Louisville, Ky. |
| 10/22/1981 | H | Western Kentucky | W | 3 | 0 | 20-14 | Louisville, Ky. |
| 10/27/1981 | A | Morehead State | L | 1 | 3 | 20-15 | Morehead, Ky. |
| 10/29/1981 | H | Northern Kentucky | W | 3 | 2 | 21-15 | Louisville, Ky. |
| 11/04/1981 | H | Xavier | W | 3 | 1 | 22-15 | Louisville, Ky. |
| 11/06/1981 | H | Mount St. Joseph | W | 2 | 0 | 23-15 | Louisville, Ky. |
| 11/06/1981 | H | Bowling Green | L | 1 | 2 | 23-16 | Louisville, Ky. |
| 11/07/1981 | H | Tennessee Tech | W | 2 | 0 | 24-16 | Louisville, Ky. |
| 11/07/1981 | H | Cincinnati | L | 0 | 2 | 24-17 | Louisville, Ky. |
| 11/10/1981 | H | Kentucky State | W | 3 | 1 | 25-17 | Louisville, Ky. |
| 11/12/1981 | A | Indiana | L | 1 | 3 | 25-18 | Bloomington, Ind. |
| 11/16/1981 | A | Bellarmine | W | 3 | 0 | 26-18 | Louisville, Ky. |