Head Coach: Leonid Yelin Record: 19-12 (13-3 C-USA)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | City | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|
| 09/03/1999 | N | Pacific | L | 0 | 3 | 0-1 | 0-0 | South Bend, Ind. | ||
| 09/04/1999 | H | Northwestern | W | 3 | 1 | 1-1 | 0-0 | South Bend, Ind. | ||
| 09/05/1999 | H | Notre Dame | L | 0 | 3 | 1-2 | 0-0 | South Bend, Ind. | ||
| 09/10/1999 | H | Nevada-Las Vegas | L | 2 | 3 | 1-3 | 0-0 | College Park, Md. | ||
| 09/10/1999 | N | Rutgers | W | 3 | 1 | 2-3 | 0-0 | College Park, Md. | ||
| 09/11/1999 | H | Maryland | L | 0 | 3 | 2-4 | 0-0 | College Park, Md. | ||
| 09/11/1999 | N | Colorado State | L | 0 | 3 | 2-5 | 0-0 | College Park, Md. | ||
| 09/14/1999 | H | Cincinnati | L | 0 | 3 | 2-6 | 0-1 | Louisville, Ky. | Conf | |
| 09/18/1999 | H | Illinois | L | 0 | 3 | 2-7 | 0-1 | Louisville, Ky. | ||
| 09/21/1999 | H | Kentucky | L | 2 | 3 | 2-8 | 0-1 | Lexington, Ky. | ||
| 09/24/1999 | A | Charlotte | W | 3 | 1 | 3-8 | 1-1 | Charlotte, N.C. | Conf | |
| 09/26/1999 | A | Saint Louis | L | 0 | 3 | 3-9 | 1-2 | Saint Louis, Mo. | Conf | |
| 10/01/1999 | H | Marquette | W | 3 | 0 | 4-9 | 2-2 | Louisville, Ky. | Conf | |
| 10/03/1999 | H | DePaul | W | 3 | 0 | 5-9 | 3-2 | Louisville, Ky. | Conf | |
| 10/08/1999 | A | Tulane | W | 3 | 0 | 6-9 | 4-2 | New Orleans, La. | Conf | |
| 10/10/1999 | H | Southern Mississippi | W | 3 | 0 | 7-9 | 5-2 | Louisville, Ky. | Conf | |
| 10/15/1999 | A | Memphis | W | 3 | 0 | 8-9 | 6-2 | Memphis, Tenn. | Conf | |
| 10/17/1999 | H | Alabama-Birmingham | W | 3 | 1 | 9-9 | 7-2 | Louisville, Ky. | Conf | |
| 10/23/1999 | H | Cincinnati | W | 3 | 0 | 10-9 | 8-2 | Louisville, Ky. | Conf | |
| 10/24/1999 | H | Kentucky | W | 3 | 0 | 11-9 | 8-2 | Louisville, Ky. | ||
| 10/29/1999 | H | Saint Louis | W | 3 | 2 | 12-9 | 9-2 | Louisville, Ky. | Conf | |
| 10/31/1999 | H | Charlotte | W | 3 | 1 | 13-9 | 10-2 | Louisville, Ky. | Conf | |
| 11/05/1999 | A | DePaul | W | 3 | 2 | 14-9 | 11-2 | Chicago, Ill. | Conf | |
| 11/07/1999 | H | Marquette | L | 2 | 3 | 14-10 | 11-3 | Milwaukee, Wis. | Conf | |
| 11/12/1999 | H | South Florida | W | 3 | 0 | 15-10 | 12-3 | Louisville, Ky. | Conf | |
| 11/14/1999 | H | Houston | W | 3 | 0 | 16-10 | 13-3 | Louisville, Ky. | Conf | |
| 11/19/1999 | N | Tulane | W | 3 | 0 | 17-10 | 13-3 | Tampa, Fla. | C-USA Championship | CT |
| 11/20/1999 | N | Houston | W | 3 | 1 | 18-10 | 13-3 | Tampa, Fla. | C-USA Championship | CT |
| 11/21/1999 | N | Cincinnati | L | 1 | 3 | 18-11 | 13-3 | Tampa, Fla. | C-USA Championship | CT |
| 11/27/1999 | H | Loyola-Chicago | W | 3 | 0 | 19-11 | 13-3 | Louisville, Ky. | ||
| 12/02/1999 | N | Kansas State | L | 0 | 3 | 19-12 | 13-3 | Fort Collins, Colo. | NCAA Championship | NCAA 1st Round |