Head Coach: Leonid Yelin Record: 26-8 (12-4 C-USA)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/26/2000 | H | Alumni (Exhibition) | W | 3 | 2 | Louisville, Ky. | |||||
| 09/01/2000 | H | Missouri-Kansas City | W | 3 | 0 | 1-0 | 0-0 | 611 | Louisville, Ky. | ||
| 09/02/2000 | H | Dayton | W | 3 | 0 | 2-0 | 0-0 | 431 | Louisville, Ky. | ||
| 09/05/2000 | A | Kentucky | W | 3 | 0 | 3-0 | 0-0 | 341 | Lexington, Ky. | ||
| 09/08/2000 | A | Loyola-Chicago | W | 3 | 0 | 4-0 | 0-0 | 290 | Chicago, Ill. | ||
| 09/09/2000 | H | Illinois | L | 1 | 3 | 4-1 | 0-0 | 175 | Chicago, Ill. | ||
| 09/09/2000 | A | Central Connecticut | W | 3 | 0 | 5-1 | 0-0 | 190 | Chicago, Ill. | ||
| 09/15/2000 | A | North Carolina | L | 0 | 3 | 5-2 | 0-0 | 200 | Chapel Hill, N.C. | ||
| 09/16/2000 | A | Delaware | W | 3 | 0 | 6-2 | 0-0 | 75 | Chapel Hill, N.C. | ||
| 09/16/2000 | A | Santa Clara | L | 1 | 3 | 6-3 | 0-0 | Chapel Hill, N.C. | |||
| 09/19/2000 | H | Cincinnati | L | 2 | 3 | 6-4 | 0-1 | 831 | Louisville, Ky. | Conf | |
| 09/22/2000 | H | Charlotte | W | 3 | 0 | 7-4 | 1-1 | 671 | Louisville, Ky. | Conf | |
| 09/23/2000 | H | Saint Louis | L | 2 | 3 | 7-5 | 1-2 | 635 | Louisville, Ky. | Conf | |
| 09/29/2000 | A | Marquette | L | 2 | 3 | 7-6 | 1-3 | 165 | Milwaukee, Wis. | Conf | |
| 09/30/2000 | A | DePaul | W | 3 | 1 | 8-6 | 2-3 | 116 | Chicago, Ill. | Conf | |
| 10/06/2000 | H | Tulane | W | 3 | 1 | 9-6 | 3-3 | 893 | Louisville, Ky. | Conf | |
| 10/08/2000 | A | Southern Mississippi | W | 3 | 0 | 10-6 | 4-3 | 98 | Hattiesburg, Miss. | Conf | |
| 10/10/2000 | H | Western Kentucky | W | 3 | 1 | 11-6 | 4-3 | 712 | Louisville, Ky. | ||
| 10/13/2000 | H | Memphis | W | 3 | 0 | 12-6 | 5-3 | 743 | Louisville, Ky. | Conf | |
| 10/14/2000 | H | Alabama-Birmingham | W | 3 | 0 | 13-6 | 6-3 | 701 | Louisville, Ky. | Conf | |
| 10/18/2000 | A | Cincinnati | W | 3 | 0 | 14-6 | 7-3 | 364 | Cincinnati, Ohio | Conf | |
| 10/24/2000 | H | Murray State | W | 3 | 0 | 15-6 | 7-3 | 482 | Louisville, Ky. | ||
| 10/27/2000 | A | Saint Louis | W | 3 | 0 | 16-6 | 8-3 | 371 | St. Louis, Mo. | Conf | |
| 10/29/2000 | A | Charlotte | W | 3 | 1 | 17-6 | 9-3 | 238 | Charlotte, N.C. | Conf | |
| 10/31/2000 | H | Illinois State | W | 3 | 1 | 18-6 | 9-3 | 313 | Louisville, Ky. | ||
| 11/03/2000 | H | DePaul | W | 3 | 2 | 19-6 | 10-3 | 601 | Louisville, Ky. | Conf | |
| 11/04/2000 | H | Marquette | W | 3 | 0 | 20-6 | 11-3 | 668 | Louisville, Ky. | Conf | |
| 11/11/2000 | A | South Florida | L | 1 | 3 | 20-7 | 11-4 | 320 | Tampa, Fla. | Conf | |
| 11/12/2000 | A | Houston | W | 3 | 0 | 21-7 | 12-4 | 271 | Houston, Texas | Conf | |
| 11/16/2000 | A | Tulane | W | 3 | 1 | 22-7 | 12-4 | 327 | Charlotte, N.C. | CT | |
| 11/18/2000 | N | Cincinnati | W | 3 | 0 | 23-7 | 12-4 | 327 | Charlotte, N.C. | C-USA Championship | CT |
| 11/19/2000 | A | South Florida | W | 3 | 0 | 24-7 | 12-4 | 451 | Charlotte, N.C. | C-USA Championship | CT |
| 11/24/2000 | H | Eastern Kentucky | W | 3 | 0 | 25-7 | 12-4 | 842 | Louisville, Ky. | ||
| 11/25/2000 | H | Kentucky | W | 3 | 0 | 26-7 | 12-4 | 962 | Louisville, Ky. | ||
| 11/30/2000 | N | Michigan | L | 1 | 3 | 26-8 | 12-4 | 922 | Tucson, Ariz. | NCAA Championship | NCAA 1st Round |