Head Coach: Anne Kordes Record: 30-4 (14-1 Big East)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/24/2012 | H | Western Kentucky | W | 3 | 1 | 1-0 | 0-0 | 2,802 | Louisville, Ky. | KFC Yum! Center | ||
| 08/25/2012 | H | 3 | Penn State | L | 0 | 3 | 1-1 | 0-0 | 4,312 | Louisville, Ky. | KFC Yum! Center | |
| 08/25/2012 | H | Morehead State | W | 3 | 1 | 2-1 | 0-0 | 1,717 | Louisville, Ky. | KFC Yum! Center | ||
| 08/29/2012 | H | 10 | Kentucky | W | 3 | 1 | 3-1 | 0-0 | 5,007 | Louisville, Ky. | KFC Yum! Center | |
| 08/31/2012 | H | Duke | W | 3 | 0 | 4-1 | 0-0 | 2,511 | Louisville, Ky. | KFC Yum! Center | ||
| 09/01/2012 | H | Samford | W | 3 | 1 | 5-1 | 0-0 | 2,413 | Louisville, Ky. | KFC Yum! Center | ||
| 09/01/2012 | H | Marshall | W | 3 | 0 | 6-1 | 0-0 | 1,803 | Louisville, Ky. | KFC Yum! Center | ||
| 09/07/2012 | N | 11 | Purdue | W | 3 | 0 | 7-1 | 0-0 | 115 | Cincinnati, Ohio | Fifth Third Arena | |
| 09/08/2012 | N | 20 | Illinois | W | 3 | 2 | 8-1 | 0-0 | 223 | Cincinnati, Ohio | Fifth Third Arena | |
| 09/14/2012 | H | Middle Tennessee | W | 3 | 0 | 9-1 | 0-0 | 2,548 | Louisville, Ky. | KFC Yum! Center | ||
| 09/15/2012 | H | Miami, Fla. | W | 3 | 1 | 10-1 | 0-0 | 2,483 | Louisville, Ky. | KFC Yum! Center | ||
| 09/15/2012 | H | Nevada-Las Vegas | W | 3 | 1 | 11-1 | 0-0 | 1,881 | Louisville, Ky. | KFC Yum! Center | ||
| 09/21/2012 | H | DePaul | W | 3 | 0 | 12-1 | 1-0 | 2,316 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 09/23/2012 | H | Notre Dame | L | 2 | 3 | 12-2 | 1-1 | 2,810 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 09/28/2012 | A | South Florida | W | 3 | 1 | 13-2 | 2-1 | 699 | Tampa, Fla. | The Corral | Conf | |
| 09/30/2012 | A | Pittsburgh | W | 3 | 0 | 14-2 | 3-1 | 257 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 10/06/2012 | H | Seton Hall | W | 3 | 0 | 15-2 | 4-1 | 785 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/07/2012 | H | Rutgers | W | 3 | 0 | 16-2 | 5-1 | 1,963 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 10/08/2012 | H | 9 | Texas | L | 2 | 3 | 16-3 | 5-1 | 4,163 | Louisville, Ky. | KFC Yum! Center | |
| 10/12/2012 | A | St. John's | W | 3 | 2 | 17-3 | 6-1 | 376 | New York, N.Y. | Taffner Field House | Conf | |
| 10/14/2012 | A | Connecticut | W | 3 | 1 | 18-3 | 7-1 | 264 | Storrs, Conn. | Gampel Pavilion | Conf | |
| 10/19/2012 | A | Syracuse | W | 3 | 0 | 19-3 | 8-1 | 111 | Syracuse, N.Y. | Women's Building | Conf | |
| 10/21/2012 | A | Marquette | W | 3 | 1 | 20-3 | 9-1 | 601 | Milwaukee, Wis. | Al McGuire Center | Conf | |
| 10/28/2012 | A | Cincinnati | W | 3 | 0 | 21-3 | 10-1 | 651 | Cincinnati, Ohio | Fifth Third Arena | Conf | |
| 11/02/2012 | H | Villanova | W | 3 | 0 | 22-3 | 11-1 | 886 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/04/2012 | H | Georgetown | W | 3 | 0 | 23-3 | 12-1 | 2,388 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 11/09/2012 | H | Marquette | W | 3 | 0 | 24-3 | 13-1 | 735 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/11/2012 | H | Cincinnati | W | 3 | 0 | 25-3 | 14-1 | 893 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/16/2012 | N | St. John's | W | 3 | 0 | 26-3 | 14-1 | Milwaukee, Wis. | Al McGuire Center | |||
| 11/17/2012 | N | Cincinnati | W | 3 | 0 | 27-3 | 14-1 | Milwaukee, Wis. | Al McGuire Center | |||
| 11/18/2012 | A | Marquette | W | 3 | 0 | 28-3 | 14-1 | 710 | Milwaukee, Wis. | Al McGuire Center | ||
| 11/23/2012 | H | Belmont | W | 3 | 0 | 29-3 | 14-1 | 897 | Louisville, Ky. | Cardinal Arena | ||
| 11/29/2012 | H | Belmont | W | 3 | 1 | 30-3 | 14-1 | 2,782 | Louisville, Ky. | KFC Yum! Center | NCAA 1st Round | |
| 11/30/2012 | H | Michigan | L | 1 | 3 | 30-4 | 14-1 | 3,412 | Louisville, Ky. | KFC Yum! Center | NCAA 2nd Round |