Head Coach: Anne Kordes Record: 24-9 (13-1 Big East)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/26/2011 | N | Tennessee Tech | W | 3 | 0 | 1-0 | 0-0 | 257 | Atlanta, Ga. | O'Keefe Gym | |
| 08/27/2011 | A | Georgia Tech | L | 2 | 3 | 1-1 | 0-0 | 1,009 | Atlanta, Ga. | O'Keefe Gym | |
| 08/27/2011 | N | Kansas State | W | 3 | 0 | 2-1 | 0-0 | 301 | Atlanta, Ga. | O'Keefe Gym | |
| 09/02/2011 | H | Mississippi | W | 3 | 0 | 3-1 | 0-0 | 979 | Louisville, Ky. | Cardinal Arena | |
| 09/03/2011 | H | Eastern Illinois | W | 3 | 0 | 4-1 | 0-0 | 746 | Louisville, Ky. | Cardinal Arena | |
| 09/03/2011 | H | Wichita State | W | 3 | 1 | 5-1 | 0-0 | 894 | Louisville, Ky. | Cardinal Arena | |
| 09/07/2011 | A | Kentucky | L | 0 | 3 | 5-2 | 0-0 | 1,617 | Lexington, Ky. | Memorial Coliseum | |
| 09/09/2011 | A | Ohio | W | 3 | 1 | 6-2 | 0-0 | Athens, Ohio | Convocation Center | ||
| 09/10/2011 | N | Virginia | W | 3 | 1 | 7-2 | 0-0 | 165 | Athens, Ohio | Convocation Center | |
| 09/10/2011 | N | Marshall | W | 3 | 0 | 8-2 | 0-0 | 127 | Athens, Ohio | Convocation Center | |
| 09/16/2011 | N | Purdue | L | 2 | 3 | 8-3 | 0-0 | 588 | Champaign, Ill. | Huff Hall | |
| 09/17/2011 | A | Illinois | L | 2 | 3 | 8-4 | 0-0 | 933 | Champaign, Ill. | Huff Hall | |
| 09/23/2011 | H | St. John's | W | 3 | 0 | 9-4 | 1-0 | 2,149 | Louisville, Ky. | KFC Yum! Center | Conf |
| 09/25/2011 | H | Connecticut | W | 3 | 0 | 10-4 | 2-0 | 2,179 | Louisville, Ky. | KFC Yum! Center | Conf |
| 09/30/2011 | A | DePaul | W | 3 | 0 | 11-4 | 3-0 | 229 | Chicago, Ill. | McGrath-Phillips Arena | Conf |
| 10/02/2011 | A | Notre Dame | W | 3 | 1 | 12-4 | 4-0 | 1,005 | Notre Dame, Ind. | Purcell Pavilion | Conf |
| 10/07/2011 | A | Seton Hall | W | 3 | 0 | 13-4 | 5-0 | 170 | South Orange, N.J. | Walsh Gymnasium | Conf |
| 10/09/2011 | A | Rutgers | W | 3 | 0 | 14-4 | 6-0 | 116 | Piscataway, N.J. | College Avenue Gym | Conf |
| 10/14/2011 | H | Cincinnati | W | 3 | 0 | 15-4 | 7-0 | 922 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/18/2011 | A | Lipscomb | L | 1 | 3 | 15-5 | 7-0 | 492 | Nashville, Tenn. | Allen Arena | |
| 10/22/2011 | H | West Virginia | W | 3 | 1 | 16-5 | 8-0 | 889 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/23/2011 | H | Pittsburgh | L | 1 | 3 | 16-6 | 8-1 | 2,202 | Louisville, Ky. | KFC Yum! Center | Conf |
| 10/28/2011 | A | South Florida | W | 3 | 0 | 17-6 | 9-1 | 400 | Tampa, Fla. | USF Upper Rec | Conf |
| 11/02/2011 | H | Tennessee | L | 0 | 3 | 17-7 | 9-1 | 2,313 | Louisville, Ky. | KFC Yum! Center | |
| 11/05/2011 | H | Syracuse | W | 3 | 1 | 18-7 | 10-1 | 2,082 | Louisville, Ky. | KFC Yum! Center | Conf |
| 11/06/2011 | H | Marquette | W | 3 | 0 | 19-7 | 11-1 | 2,111 | Louisville, Ky. | KFC Yum! Center | Conf |
| 11/11/2011 | A | Villanova | W | 3 | 2 | 20-7 | 12-1 | 311 | Philadelphia, Pa. | Jake Nevin Field House | Conf |
| 11/13/2011 | A | Georgetown | W | 3 | 0 | 21-7 | 13-1 | 275 | Washington, D.C. | McDonough Arena | Conf |
| 11/18/2011 | N | Pittsburgh | W | 3 | 1 | 22-7 | 13-1 | Milwaukee, Wis. | Al McGuire Center | ||
| 11/19/2011 | N | Notre Dame | L | 1 | 3 | 22-8 | 13-1 | Milwaukee, Wis. | Al McGuire Center | ||
| 11/26/2011 | H | Morehead State | W | 3 | 0 | 23-8 | 13-1 | 857 | Louisville, Ky. | Cardinal Arena | |
| 12/02/2011 | N | Ball State | W | 3 | 0 | 24-8 | 13-1 | West Lafayette, Ind. | Holloway Gymnasium | NCAA 1st Round | |
| 12/03/2011 | A | Purdue | L | 1 | 3 | 24-9 | 13-1 | 2,036 | West Lafayette, Ind. | Holloway Gymnasium | NCAA 2nd Round |