Head Coach: Anne Kordes Record: 25-7 (18-2 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/28/2015 | A | 8 | Illinois | L | 0 | 3 | 0-1 | 0-0 | 3,344 | Champaign, Ill. | Huff Hall | ||
| 08/29/2015 | N | Creighton | W | 3 | 2 | 1-1 | 0-0 | 3,005 | Champaign, Ill. | Huff Hall | |||
| 08/29/2015 | N | Miami, Ohio | W | 3 | 1 | 2-1 | 0-0 | 3,005 | Champaign, Ill. | Huff Hall | |||
| 09/04/2015 | H | Minnesota | L | 2 | 3 | 2-2 | 0-0 | 2,535 | Louisville, Ky. | KFC Yum! Center | |||
| 09/05/2015 | H | 13 | Wisconsin | L | 1 | 3 | 2-3 | 0-0 | 2,861 | Louisville, Ky. | KFC Yum! Center | ||
| 09/11/2015 | H | Utah | W | 3 | 0 | 3-3 | 0-0 | 899 | Louisville, Ky. | Cardinal Arena | Active Ankle Challenge | ||
| 09/12/2015 | H | Seton Hall | W | 3 | 0 | 4-3 | 0-0 | 632 | Louisville, Ky. | Cardinal Arena | Active Ankle Challenge | ||
| 09/12/2015 | H | Ohio | W | 3 | 2 | 5-3 | 0-0 | 902 | Louisville, Ky. | Cardinal Arena | Active Ankle Challenge | ||
| 09/17/2015 | A | Cincinnati | W | 3 | 1 | 6-3 | 0-0 | 731 | Cincinnati, Ohio | Fifth Third Arena | |||
| 09/20/2015 | A | 24 | Kentucky | L | 1 | 3 | 6-4 | 0-0 | 3,338 | Lexington, Ky. | Memorial Coliseum | ||
| 09/25/2015 | A | Notre Dame | W | 3 | 0 | 7-4 | 1-0 | 1,505 | Notre Dame, Ind. | Purcell Pavilion | Conf | ||
| 09/27/2015 | H | Miami, Fla. | W | 3 | 1 | 8-4 | 2-0 | 2,372 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/02/2015 | H | Syracuse | W | 3 | 1 | 9-4 | 3-0 | 2,192 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/04/2015 | H | Boston College | W | 3 | 0 | 10-4 | 4-0 | 2,133 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/09/2015 | A | Georgia Tech | W | 3 | 0 | 11-4 | 5-0 | 1,125 | Atlanta, Ga. | O'Keefe Gym | Conf | ||
| 10/11/2015 | A | Clemson | W | 3 | 0 | 12-4 | 6-0 | 603 | Clemson, S.C. | Jervey Gymnasium | Conf | ||
| 10/16/2015 | H | Wake Forest | W | 3 | 0 | 13-4 | 7-0 | 2,341 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/18/2015 | H | Duke | W | 3 | 0 | 14-4 | 8-0 | 2,492 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/21/2015 | H | Notre Dame | W | 3 | 0 | 15-4 | 9-0 | 2,156 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/24/2015 | A | Virginia | W | 3 | 0 | 16-4 | 10-0 | 677 | Charlottesville, Va. | Memorial Gymnasium | Conf | ||
| 10/30/2015 | A | North Carolina | L | 1 | 3 | 16-5 | 10-1 | 1,345 | Chapel Hill, N.C. | Carmichael Arena | Conf | ||
| 11/01/2015 | A | North Carolina State | W | 3 | 0 | 17-5 | 11-1 | 422 | Raleigh, N.C. | Carmichael Gym | Conf | ||
| 11/06/2015 | H | Pittsburgh | W | 3 | 2 | 18-5 | 12-1 | 2,523 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 11/08/2015 | H | Virginia Tech | W | 3 | 0 | 19-5 | 13-1 | 2,244 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 11/13/2015 | A | Miami, Fla. | W | 3 | 1 | 20-5 | 14-1 | 392 | Coral Gables, Fla. | James L. Knight Sports Complex | Conf | ||
| 11/15/2015 | A | 20 | Florida State | W | 3 | 2 | 21-5 | 15-1 | 1,147 | Tallahassee, Fla. | Tully Gymnasium | Conf | |
| 11/20/2015 | H | Clemson | W | 3 | 0 | 22-5 | 16-1 | 3,231 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 11/22/2015 | H | Georgia Tech | W | 3 | 0 | 23-5 | 17-1 | Louisville, Ky. | KFC Yum! Center | Conf | |||
| 11/25/2015 | A | Boston College | W | 3 | 1 | 24-5 | 18-1 | 131 | Boston, Mass. | Power Gym | Conf | ||
| 11/27/2015 | A | Syracuse | L | 0 | 3 | 24-6 | 18-2 | 252 | Syracuse, N.Y. | Women's Building | Conf | ||
| 12/04/2015 | H | Belmont | W | 3 | 1 | 25-6 | 18-2 | 1,082 | Louisville, Ky. | Cardinal Arena | NCAA 1st Round | ||
| 12/05/2015 | H | 21 | Illinois | L | 1 | 3 | 25-7 | 18-2 | 1,024 | Louisville, Ky. | Cardinal Arena | NCAA 2nd Round |