Head Coach: Anne Kordes Record: 12-18 (7-13 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/26/2016 | N | Oakland | W | 3 | 1 | 1-0 | 0-0 | Bowling Green, Ohio | Stroh Center | Bowling Green Tournament | |||
| 08/26/2016 | N | Virginia Commonwealth | W | 3 | 0 | 2-0 | 0-0 | Bowling Green, Ohio | Stroh Center | Bowling Green Tournament | |||
| 08/27/2016 | A | Bowling Green | W | 3 | 2 | 3-0 | 0-0 | 748 | Bowling Green, Ohio | Stroh Center | Bowling Green Tournament | ||
| 09/02/2016 | H | Santa Clara | L | 1 | 3 | 3-1 | 0-0 | 2,179 | Louisville, Ky. | KFC Yum! Center | Active Ankle Challenge | ||
| 09/03/2016 | H | Stony Brook | W | 3 | 1 | 4-1 | 0-0 | 1,941 | Louisville, Ky. | KFC Yum! Center | Active Ankle Challenge | ||
| 09/03/2016 | H | Auburn | L | 2 | 3 | 4-2 | 0-0 | 2,436 | Louisville, Ky. | KFC Yum! Center | Active Ankle Challenge | ||
| 09/09/2016 | N | 5 | Minnesota | L | 0 | 3 | 4-3 | 0-0 | Chapel Hill, N.C. | Carmichael Arena | |||
| 09/10/2016 | N | 2 | Wisconsin | L | 0 | 3 | 4-4 | 0-0 | Chapel Hill, N.C. | Carmichael Arena | |||
| 09/15/2016 | H | Kentucky | L | 0 | 3 | 4-5 | 0-0 | 3,531 | Louisville, Ky. | KFC Yum! Center | |||
| 09/16/2016 | H | Lipscomb | W | 3 | 2 | 5-5 | 0-0 | 736 | Louisville, Ky. | Cardinal Arena | |||
| 09/23/2016 | A | Notre Dame | L | 0 | 3 | 5-6 | 0-1 | 1,222 | South Bend, Ind. | Purcell Pavilion | Conf | ||
| 09/25/2016 | A | 15 | Florida State | L | 1 | 3 | 5-7 | 0-2 | 1,125 | Tallahassee, Fla. | Tully Gymnasium | Conf | |
| 09/30/2016 | H | Wake Forest | L | 1 | 3 | 5-8 | 0-3 | 2,086 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/02/2016 | H | Duke | L | 0 | 3 | 5-9 | 0-4 | 2,192 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/06/2016 | A | Boston College | W | 3 | 2 | 6-9 | 1-4 | 115 | Chestnut Hill, Mass. | Power Gym | Conf | ||
| 10/09/2016 | A | Syracuse | L | 2 | 3 | 6-10 | 1-5 | 110 | Syracuse, N.Y. | Women's Building | Conf | ||
| 10/13/2016 | H | North Carolina State | L | 0 | 3 | 6-11 | 1-6 | 1,743 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/16/2016 | H | 8 | North Carolina | L | 0 | 3 | 6-12 | 1-7 | 2,231 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 10/21/2016 | A | Virginia Tech | W | 3 | 1 | 7-12 | 2-7 | 652 | Blacksburg, Va. | Cassell Coliseum | Conf | ||
| 10/23/2016 | A | Pittsburgh | L | 0 | 3 | 7-13 | 2-8 | 549 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | ||
| 10/28/2016 | H | 11 | Florida State | L | 1 | 3 | 7-14 | 2-9 | 2,082 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 10/30/2016 | H | Miami, Fla. | L | 2 | 3 | 7-15 | 2-10 | 1,861 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 11/04/2016 | A | Duke | L | 0 | 3 | 7-16 | 2-11 | 865 | Durham, N.C. | Cameron Indoor Stadium | Conf | ||
| 11/06/2016 | A | Wake Forest | W | 3 | 0 | 8-16 | 3-11 | 112 | Winston-Salem, N.C. | Summit School | Conf | ||
| 11/09/2016 | H | Notre Dame | W | 3 | 1 | 9-16 | 4-11 | 1,842 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 11/11/2016 | H | Virginia | L | 0 | 3 | 9-17 | 4-12 | 983 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/18/2016 | A | Georgia Tech | L | 1 | 3 | 9-18 | 4-13 | 690 | Atlanta, Ga. | O'Keefe Gym | Conf | ||
| 11/20/2016 | A | Clemson | W | 3 | 0 | 10-18 | 5-13 | 523 | Clemson, S.C. | Jervey Gymnasium | Conf | ||
| 11/23/2016 | H | Syracuse | W | 3 | 1 | 11-18 | 6-13 | 1,828 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 11/25/2016 | H | Boston College | W | 3 | 0 | 12-18 | 7-13 | 1,811 | Louisville, Ky. | KFC Yum! Center | Conf |