Head Coach: Dani Busboom Kelly Record: 15-3 (12-2 ACC)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/25/2020 | H | Notre Dame | L | 0 | 3 | 0-1 | 0-1 | 150 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/02/2020 | A | Boston College | W | 3 | 0 | 1-1 | 1-1 | Chestnut Hill, Mass. | Power Gym | Conf | ||
| 10/03/2020 | A | Boston College | W | 3 | 1 | 2-1 | 2-1 | Chestnut Hill, Mass. | Power Gym | Conf | ||
| 10/09/2020 | H | Syracuse | W | 3 | 0 | 3-1 | 3-1 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/10/2020 | H | Syracuse | W | 3 | 0 | 4-1 | 4-1 | 150 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/23/2020 | A | Pittsburgh | L | 0 | 3 | 4-2 | 4-2 | 183 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 10/25/2020 | A | Pittsburgh | W | 3 | 1 | 5-2 | 5-2 | 246 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 03/06/2021 | H | Wake Forest | W | 3 | 0 | 6-2 | 5-2 | 150 | Louisville, Ky. | L&N Federal Credit Union Arena | ||
| 03/07/2021 | H | Wake Forest | W | 3 | 0 | 7-2 | 6-2 | 150 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 03/13/2021 | N | Duke | W | 3 | 0 | 8-2 | 7-2 | Clemson, S.C. | Conf | |||
| 03/14/2021 | A | Duke | W | 3 | 0 | 9-2 | 7-2 | Durham, N.C. | Cameron Indoor Stadium | |||
| 03/20/2021 | N | Florida State | W | 3 | 1 | 10-2 | 8-2 | 26 | Charlottesville, Va. | Memorial Gymnasium | Conf | |
| 03/26/2021 | H | Georgia Tech | W | 3 | 0 | 11-2 | 9-2 | 236 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 03/28/2021 | H | North Carolina State | W | 3 | 0 | 12-2 | 10-2 | 236 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 04/01/2021 | A | Miami, Fla. | W | 3 | 1 | 13-2 | 11-2 | 1 | Coral Gables, Fla. | James L. Knight Sports Complex | Conf | |
| 04/02/2021 | N | North Carolina | W | 3 | 0 | 14-2 | 12-2 | Coral Gables, Fla. | James L. Knight Sports Complex | Conf | ||
| 04/15/2021 | N | San Diego | W | 3 | 1 | 15-2 | 12-2 | Omaha, Neb. | CHI Health Center Omaha | NCAA Championship | NCAA 2nd Round | |
| 04/18/2021 | N | Washington | L | 2 | 3 | 15-3 | 12-2 | Omaha, Neb. | CHI Health Center Omaha | NCAA Championship | NCAA Regional Semifinal |