Head Coach: Dani Busboom Kelly Record: 22-10 (12-6 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/30/2019 | H | 10 | Florida | L | 0 | 3 | 0-1 | 0-0 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | ||
| 08/31/2019 | H | Texas A&M | W | 3 | 2 | 1-1 | 0-0 | 1,016 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | ||
| 09/01/2019 | H | Dayton | W | 3 | 0 | 2-1 | 0-0 | 35 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | ||
| 09/06/2019 | H | Tennessee Tech | W | 3 | 0 | 3-1 | 0-0 | 92 | Louisville, Ky. | L&N Federal Credit Union Arena | Fleur de Lis Tournament | ||
| 09/06/2019 | H | Western Kentucky | W | 3 | 1 | 4-1 | 0-0 | 1,018 | Louisville, Ky. | L&N Federal Credit Union Arena | Fleur de Lis Tournament | ||
| 09/07/2019 | H | Arizona State | W | 3 | 1 | 5-1 | 0-0 | 844 | Louisville, Ky. | L&N Federal Credit Union Arena | Fleur de Lis Tournament | ||
| 09/13/2019 | N | 23 | Purdue | L | 1 | 3 | 5-2 | 0-0 | 120 | Nashville, Tenn. | Allen Arena | Lipscomb Tournament | |
| 09/14/2019 | A | Xavier | W | 3 | 0 | 6-2 | 0-0 | 115 | Nashville, Tenn. | Allen Arena | Lipscomb Tournament | ||
| 09/20/2019 | A | 16 | Kentucky | L | 0 | 3 | 6-3 | 0-0 | 3,022 | Lexington, Ky. | Memorial Coliseum | ||
| 09/22/2019 | A | Cincinnati | W | 3 | 2 | 7-3 | 0-0 | 1,019 | Cincinnati, Ohio | Saint Ursula Academy Gymnasium & Convocation Center | |||
| 09/27/2019 | H | North Carolina State | W | 3 | 2 | 8-3 | 1-0 | 832 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 09/29/2019 | H | North Carolina | W | 3 | 1 | 9-3 | 2-0 | 906 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/04/2019 | H | Georgia Tech | W | 3 | 0 | 10-3 | 3-0 | 42 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/06/2019 | H | Clemson | W | 3 | 0 | 11-3 | 4-0 | 189 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/11/2019 | A | Duke | W | 3 | 0 | 12-3 | 5-0 | 42 | Durham, N.C. | Cameron Indoor Stadium | Conf | ||
| 10/13/2019 | A | Wake Forest | W | 3 | 0 | 13-3 | 6-0 | 413 | Winston-Salem, N.C. | Reynolds Gym | Conf | ||
| 10/16/2019 | A | Notre Dame | W | 3 | 2 | 14-3 | 7-0 | 246 | South Bend, Ind. | Purcell Pavilion | Conf | ||
| 10/20/2019 | A | Virginia Tech | L | 1 | 3 | 14-4 | 7-1 | 547 | Blacksburg, Va. | Cassell Coliseum | Conf | ||
| 10/25/2019 | H | Virginia | W | 3 | 0 | 15-4 | 8-1 | 900 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/27/2019 | H | Pittsburgh | L | 0 | 3 | 15-5 | 8-2 | 1,065 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/01/2019 | A | Boston College | L | 2 | 3 | 15-6 | 8-3 | 247 | Chestnut Hill, Mass. | Power Gym | Conf | ||
| 11/03/2019 | A | Syracuse | L | 2 | 3 | 15-7 | 8-4 | 117 | Syracuse, N.Y. | Women's Building | Conf | ||
| 11/08/2019 | A | Miami, Fla. | W | 3 | 2 | 16-7 | 9-4 | 530 | Coral Gables, Fla. | James L. Knight Sports Complex | Conf | ||
| 11/10/2019 | A | Florida State | L | 1 | 3 | 16-8 | 9-5 | 452 | Tallahassee, Fla. | Tully Gymnasium | Conf | ||
| 11/15/2019 | H | Syracuse | W | 3 | 0 | 17-8 | 10-5 | 41 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/22/2019 | H | Notre Dame | W | 3 | 0 | 18-8 | 11-5 | 1,074 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/24/2019 | H | Miami, Fla. | W | 3 | 0 | 19-8 | 12-5 | 970 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/27/2019 | A | 2 | Pittsburgh | L | 1 | 3 | 19-9 | 12-6 | 1,734 | Pittsburgh, Pa. | Petersen Events Center | Conf | |
| 12/05/2019 | N | Samford | W | 3 | 0 | 20-9 | 12-6 | Bowling Green, Ky. | E.A. Diddle Arena | NCAA Volleyball Championship | NCAA 1st Round | ||
| 12/06/2019 | N | 19 | Western Kentucky | W | 3 | 2 | 21-9 | 12-6 | 5,023 | Bowling Green, Ky. | E.A. Diddle Arena | NCAA Volleyball Championship | NCAA 2nd Round |
| 12/13/2019 | A | 2 | Texas | W | 3 | 2 | 22-9 | 12-6 | Austin, Texas | Gregory Gym | NCAA Volleyball Championship | NCAA Regional Semifinal | |
| 12/14/2019 | N | 7 | Minnesota | L | 0 | 3 | 22-10 | 12-6 | 3,915 | Austin, Texas | Gregory Gym | NCAA Championship | NCAA Regional Final |