Head Coach: Dani Busboom Kelly Record: 31-3 (17-1 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/26/2022 | N | Northern Kentucky | W | 3 | 0 | 1-0 | 0-0 | 125 | Vermillion, S.D. | Sanford Coyote Sports Center | |||
| 08/26/2022 | A | South Dakota | W | 3 | 0 | 2-0 | 0-0 | 2,774 | Vermillion, S.D. | Sanford Coyote Sports Center | |||
| 08/27/2022 | N | Missouri | W | 3 | 0 | 3-0 | 0-0 | 289 | Vermillion, S.D. | Sanford Coyote Sports Center | |||
| 08/31/2022 | A | 22 | Western Kentucky | W | 3 | 0 | 4-0 | 0-0 | 4,021 | Bowling Green, Ky. | E.A. Diddle Arena | ||
| 09/02/2022 | H | 15 | San Diego | W | 3 | 1 | 5-0 | 0-0 | 997 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | |
| 09/04/2022 | H | 8 | Ohio State | L | 1 | 3 | 5-1 | 0-0 | 1,000 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | |
| 09/09/2022 | H | 9 | Purdue | W | 3 | 0 | 6-1 | 0-0 | 987 | Louisville, Ky. | L&N Federal Credit Union Arena | Louisville Invitational | |
| 09/10/2022 | H | Lipscomb | W | 3 | 0 | 7-1 | 0-0 | 972 | Louisville, Ky. | L&N Federal Credit Union Arena | Louisville Invitational | ||
| 09/14/2022 | A | 13 | Kentucky | W | 3 | 2 | 8-1 | 0-0 | 3,756 | Lexington, Ky. | Memorial Coliseum | ||
| 09/17/2022 | A | 9 | Stanford | W | 3 | 1 | 9-1 | 0-0 | 2,426 | Stanford, Calif. | Maples Pavilion | ||
| 09/23/2022 | A | Miami, Fla. | W | 3 | 0 | 10-1 | 1-0 | 1,074 | Coral Gables, Fla. | James L. Knight Sports Complex | Conf | ||
| 09/25/2022 | A | Florida State | W | 3 | 0 | 11-1 | 2-0 | Tallahassee, Fla. | Tully Gymnasium | Conf | |||
| 09/30/2022 | H | Clemson | W | 3 | 0 | 12-1 | 3-0 | 1,015 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/02/2022 | H | 11 | Georgia Tech | W | 3 | 1 | 13-1 | 4-0 | 999 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/07/2022 | A | Boston College | W | 3 | 0 | 14-1 | 5-0 | 556 | Chestnut Hill, Mass. | Connell Recreation Center | Conf | ||
| 10/09/2022 | A | Syracuse | W | 3 | 0 | 15-1 | 6-0 | 355 | Syracuse, N.Y. | Women's Building | Conf | ||
| 10/14/2022 | H | Virginia Tech | W | 3 | 1 | 16-1 | 7-0 | 1,018 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/16/2022 | H | Wake Forest | W | 3 | 1 | 17-1 | 8-0 | 995 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/21/2022 | A | Virginia | W | 3 | 0 | 18-1 | 9-0 | 534 | Charlottesville, Va. | Memorial Gymnasium | Conf | ||
| 10/23/2022 | A | 8 | Pittsburgh | L | 2 | 3 | 18-2 | 9-1 | 2,686 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 10/26/2022 | H | Notre Dame | W | 3 | 0 | 19-2 | 10-1 | 9,058 | Louisville, Ky. | KFC Yum! Center | Conf | ||
| 10/28/2022 | H | Duke | W | 3 | 0 | 20-2 | 11-1 | 982 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/04/2022 | H | North Carolina State | W | 3 | 0 | 21-2 | 12-1 | 1,028 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/06/2022 | H | North Carolina | W | 3 | 1 | 22-2 | 13-1 | 982 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/11/2022 | A | 13 | Georgia Tech | W | 3 | 2 | 23-2 | 14-1 | 1,200 | Atlanta, Ga. | O'Keefe Gym | Conf | |
| 11/13/2022 | A | North Carolina | W | 3 | 0 | 24-2 | 15-1 | 1,678 | Chapel Hill, N.C. | Carmichael Arena | Conf | ||
| 11/18/2022 | H | 7 | Pittsburgh | W | 3 | 0 | 25-2 | 16-1 | 1,014 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 11/23/2022 | A | Notre Dame | W | 3 | 0 | 26-2 | 17-1 | 1,132 | South Bend, Ind. | Purcell Pavilion at the Joyce Center | Conf | ||
| 12/02/2022 | H | Samford | W | 3 | 0 | 27-2 | 17-1 | 933 | Louisville, Ky. | L&N Federal Credit Union Arena | NCAA Volleyball Championship | NCAA 1st Round | |
| 12/03/2022 | H | 19 | Purdue | W | 3 | 0 | 28-2 | 17-1 | 984 | Louisville, Ky. | L&N Federal Credit Union Arena | NCAA Volleyball Championship | NCAA 2nd Round |
| 12/08/2022 | H | 17 | Baylor | W | 3 | 0 | 29-2 | 17-1 | 5,002 | Louisville, Ky. | KFC Yum! Center | NCAA Volleyball Championship | NCAA Regional Semifinal |
| 12/10/2022 | H | 9 | Oregon | W | 3 | 2 | 30-2 | 17-1 | 8,749 | Louisville, Ky. | KFC Yum! Center | NCAA Volleyball Championship | NCAA Regional Final |
| 12/15/2022 | N | 6 | Pittsburgh | W | 3 | 2 | 31-2 | 17-1 | 16,735 | Omaha, Neb. | CHI Health Center Omaha | NCAA Volleyball Championship | NCAA National Semifinal |
| 12/17/2022 | N | 1 | Texas | L | 0 | 3 | 31-3 | 17-1 | 16,952 | Omaha, Neb. | CHI Health Center Omaha | NCAA Volleyball Championship | NCAA National Final |