Head Coach: Dani Busboom Kelly Record: 27-5 (15-3 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/25/2023 | H | Troy | W | 3 | 0 | 1-0 | 0-0 | 992 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | ||
| 08/26/2023 | H | 21 | Washington State | W | 3 | 0 | 2-0 | 0-0 | 989 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | |
| 08/27/2023 | H | Wright State | W | 3 | 1 | 3-0 | 0-0 | 992 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | ||
| 09/01/2023 | N | South Dakota | W | 3 | 0 | 4-0 | 0-0 | 152 | Columbia, Mo. | Hearnes Center | Mizzou Invitational | ||
| 09/02/2023 | N | Northern Kentucky | W | 3 | 0 | 5-0 | 0-0 | 127 | Columbia, Mo. | Hearnes Center | Mizzou Invitational | ||
| 09/03/2023 | N | Missouri | W | 3 | 0 | 6-0 | 0-0 | 2,503 | Columbia, Mo. | Hearnes Center | Mizzou Invitational | ||
| 09/06/2023 | A | Dayton | W | 3 | 2 | 7-0 | 0-0 | 1,113 | Dayton, Ohio | Frericks Center | |||
| 09/10/2023 | H | 12 | Penn State | W | 3 | 0 | 8-0 | 0-0 | 1,079 | Louisville, Ky. | L&N Federal Credit Union Arena | ||
| 09/13/2023 | H | 21 | Kentucky | W | 3 | 0 | 9-0 | 0-0 | 12,760 | Louisville, Ky. | KFC Yum! Center | ||
| 09/17/2023 | H | 5 | Stanford | L | 2 | 3 | 9-1 | 0-0 | 9,761 | Louisville, Ky. | KFC Yum! Center | ||
| 09/22/2023 | H | Syracuse | W | 3 | 0 | 10-1 | 1-0 | 1,061 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 09/24/2023 | H | Boston College | W | 3 | 1 | 11-1 | 2-0 | 1,161 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 09/27/2023 | A | Notre Dame | W | 3 | 0 | 12-1 | 3-0 | 1,472 | South Bend, Ind. | Purcell Pavilion at the Joyce Center | Conf | ||
| 10/01/2023 | A | North Carolina State | L | 1 | 3 | 12-2 | 3-1 | 2,870 | Raleigh, N.C. | Reynolds Coliseum | Conf | ||
| 10/06/2023 | A | North Carolina | W | 3 | 1 | 13-2 | 4-1 | 1,175 | Chapel Hill, N.C. | Carmichael Arena | Conf | ||
| 10/08/2023 | A | Duke | W | 3 | 0 | 14-2 | 5-1 | 1,437 | Durham, N.C. | Cameron Indoor Stadium | Conf | ||
| 10/13/2023 | H | 8 | Pittsburgh | W | 3 | 0 | 15-2 | 6-1 | 11,461 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 10/15/2023 | H | Virginia | W | 3 | 0 | 16-2 | 7-1 | 1,002 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/20/2023 | A | Wake Forest | W | 3 | 2 | 17-2 | 8-1 | 712 | Winston-Salem, N.C. | Reynolds Gym | Conf | ||
| 10/22/2023 | A | Virginia Tech | W | 3 | 1 | 18-2 | 9-1 | 835 | Blacksburg, Va. | Cassell Coliseum | Conf | ||
| 10/27/2023 | H | Florida State | W | 3 | 0 | 19-2 | 10-1 | 1,015 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 10/29/2023 | H | Miami, Fla. | W | 3 | 0 | 20-2 | 11-1 | 1,022 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/03/2023 | A | 10 | Georgia Tech | L | 1 | 3 | 20-3 | 11-2 | 1,200 | Atlanta, Ga. | O'Keefe Gym | Conf | |
| 11/05/2023 | A | Clemson | W | 3 | 1 | 21-3 | 12-2 | 1,360 | Clemson, S.C. | Jervey Gymnasium | Conf | ||
| 11/10/2023 | H | Duke | W | 3 | 0 | 22-3 | 13-2 | 1,042 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/12/2023 | H | North Carolina | W | 3 | 0 | 23-3 | 14-2 | 1,036 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/18/2023 | A | 7 | Pittsburgh | L | 2 | 3 | 23-4 | 14-3 | 8,865 | Pittsburgh, Pa. | Petersen Events Center | Conf | |
| 11/22/2023 | H | Georgia Tech | W | 3 | 1 | 24-4 | 15-3 | 1,083 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | ||
| 11/30/2023 | H | Wright State | W | 3 | 1 | 25-4 | 15-3 | 5,035 | Louisville, Ky. | KFC Yum! Center | NCAA Championship | NCAA 1st Round | |
| 12/01/2023 | H | Western Michigan | W | 3 | 0 | 26-4 | 15-3 | 5,529 | Louisville, Ky. | KFC Yum! Center | NCAA Championship | NCAA 2nd Round | |
| 12/07/2023 | N | 3 | Creighton | W | 3 | 2 | 27-4 | 15-3 | 2,879 | Pittsburgh, Pa. | Fitzgerald Field House | NCAA Regional Semifinal | |
| 12/09/2023 | A | 4 | Pittsburgh | L | 2 | 3 | 27-5 | 15-3 | 2,879 | Pittsburgh, Pa. | Fitzgerald Field House | NCAA Regional Final |