Head Coach: Leonid Yelin Record: 30-3 (13-0 C-USA)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/03/2004 | H | Virginia | W | 3 | 1 | 1-0 | 0-0 | 942 | Louisville, Ky. | Cardinal Arena | ||
| 09/04/2004 | H | Jacksonville State | W | 3 | 1 | 2-0 | 0-0 | 897 | Louisville, Ky. | Cardinal Arena | ||
| 09/04/2004 | H | Loyola, Md. | W | 3 | 0 | 3-0 | 0-0 | 241 | Louisville, Ky. | Cardinal Arena | ||
| 09/09/2004 | A | Nicholls State | W | 3 | 1 | 4-0 | 0-0 | 20 | Tucson, Ariz. | McKale Center | ||
| 09/10/2004 | H | 9 | Pepperdine | W | 3 | 1 | 5-0 | 0-0 | 213 | Tucson, Ariz. | McKale Center | |
| 09/11/2004 | A | 19 | Arizona | L | 1 | 3 | 5-1 | 0-0 | 400 | Tucson, Ariz. | McKale Center | |
| 09/17/2004 | H | Wake Forest | W | 3 | 2 | 6-1 | 0-0 | 76 | Dayton, Ohio | C.J. McLin Gymnasium | ||
| 09/18/2004 | A | Morehead State | W | 3 | 0 | 7-1 | 0-0 | 53 | Dayton, Ohio | C.J. McLin Gymnasium | ||
| 09/18/2004 | A | Wright State | W | 3 | 0 | 8-1 | 0-0 | 138 | Dayton, Ohio | C.J. McLin Gymnasium | ||
| 09/22/2004 | A | 24 | Tennessee | L | 1 | 3 | 8-2 | 0-0 | 334 | Knoxville, Tenn. | Stokely Athletic Center | |
| 09/25/2004 | H | Xavier | W | 3 | 0 | 9-2 | 0-0 | 512 | Louisville, Ky. | Cardinal Arena | ||
| 10/01/2004 | A | DePaul | W | 3 | 1 | 10-2 | 1-0 | 305 | Chicago, Ill. | DePaul Athletic Center | Conf | |
| 10/02/2004 | A | Marquette | W | 3 | 0 | 11-2 | 2-0 | 733 | Milwaukee, Wis. | Al McGuire Center | Conf | |
| 10/05/2004 | H | Morehead State | W | 3 | 0 | 12-2 | 2-0 | 623 | Louisville, Ky. | Cardinal Arena | ||
| 10/08/2004 | H | South Florida | W | 3 | 0 | 13-2 | 3-0 | 927 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/09/2004 | H | Alabama-Birmingham | W | 3 | 0 | 14-2 | 4-0 | 710 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/15/2004 | A | Texas Christian | W | 3 | 0 | 15-2 | 5-0 | 282 | Fort Worth, Texas | University Recreation Center | Conf | |
| 10/16/2004 | A | Houston | W | 3 | 0 | 16-2 | 6-0 | Houston, Texas | Conf | |||
| 10/23/2004 | H | Saint Louis | W | 3 | 0 | 17-2 | 7-0 | 641 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/24/2004 | H | Memphis | W | 3 | 0 | 18-2 | 8-0 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/29/2004 | A | Tulane | W | 3 | 0 | 19-2 | 9-0 | 321 | New Orleans, La. | Fogelman Arena | Conf | |
| 10/30/2004 | A | Southern Mississippi | W | 3 | 0 | 20-2 | 10-0 | 145 | Hattiesburg, Miss. | Payne Center | Conf | |
| 11/05/2004 | H | East Carolina | W | 3 | 0 | 21-2 | 11-0 | 948 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/06/2004 | H | Charlotte | W | 3 | 0 | 22-2 | 12-0 | 897 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/09/2004 | A | Kentucky | W | 3 | 0 | 23-2 | 12-0 | Lexington, Ky. | ||||
| 11/12/2004 | H | Cincinnati | W | 3 | 0 | 24-2 | 13-0 | 1,084 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/20/2004 | H | Houston | W | 3 | 0 | 25-2 | 13-0 | Louisville, Ky. | Cardinal Arena | CT | ||
| 11/21/2004 | H | Memphis | W | 3 | 0 | 26-2 | 13-0 | Louisville, Ky. | Cardinal Arena | CT | ||
| 11/22/2004 | H | Marquette | W | 3 | 0 | 27-2 | 13-0 | 904 | Louisville, Ky. | Cardinal Arena | CT | |
| 11/27/2004 | H | Pittsburgh | W | 3 | 0 | 28-2 | 13-0 | 497 | Louisville, Ky. | Cardinal Arena | ||
| 12/03/2004 | H | Illinois | W | 3 | 1 | 29-2 | 13-0 | Columbia, Mo. | NCAA 1st Round | |||
| 12/04/2004 | A | 24 | Missouri | W | 3 | 1 | 30-2 | 13-0 | Columbia, Mo. | NCAA 2nd Round | ||
| 12/10/2004 | H | 1 | Nebraska | L | 0 | 3 | 30-3 | 13-0 | Louisville, Ky. | Kentucky International Convention Center | NCAA Regional Semifinal |