Head Coach: Leonid Yelin Record: 31-3 (13-1 Big East)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/02/2005 | H | Wake Forest | W | 3 | 0 | 1-0 | 0-0 | 664 | Louisville, Ky. | Cardinal Arena | ||
| 09/03/2005 | H | Tennessee State | W | 3 | 0 | 2-0 | 0-0 | 762 | Louisville, Ky. | Cardinal Arena | ||
| 09/04/2005 | H | Ohio | W | 3 | 0 | 3-0 | 0-0 | 612 | Louisville, Ky. | Cardinal Arena | ||
| 09/07/2005 | H | Kentucky | W | 3 | 0 | 4-0 | 0-0 | 989 | Louisville, Ky. | Cardinal Arena | ||
| 09/09/2005 | H | Illinois | W | 3 | 0 | 5-0 | 0-0 | Las Vegas, Nev. | ||||
| 09/10/2005 | A | 22 | Long Beach State | W | 3 | 0 | 6-0 | 0-0 | Las Vegas, Nev. | Cox Pavilion | ||
| 09/16/2005 | A | Michigan State | W | 3 | 2 | 7-0 | 0-0 | Coral Gables, Fla. | James L. Knight Sports Complex | |||
| 09/17/2005 | A | Sacramento State | W | 3 | 0 | 8-0 | 0-0 | 112 | Coral Gables, Fla. | James L. Knight Sports Complex | ||
| 09/17/2005 | A | Miami, Fla. | W | 3 | 1 | 9-0 | 0-0 | 512 | Coral Gables, Fla. | James L. Knight Sports Complex | ||
| 09/24/2005 | H | Connecticut | W | 3 | 0 | 10-0 | 1-0 | 712 | Louisville, Ky. | Cardinal Arena | Conf | |
| 09/25/2005 | H | St. John's | W | 3 | 1 | 11-0 | 2-0 | 699 | Louisville, Ky. | Cardinal Arena | Conf | |
| 09/28/2005 | H | Tennessee | W | 3 | 2 | 12-0 | 2-0 | 947 | Louisville, Ky. | Cardinal Arena | ||
| 10/01/2005 | A | Villanova | W | 3 | 0 | 13-0 | 3-0 | 221 | Villanova, Pa. | Jake Nevin Field House | Conf | |
| 10/02/2005 | A | Rutgers | W | 3 | 0 | 14-0 | 4-0 | 140 | Piscataway, N.J. | College Avenue Gym | Conf | |
| 10/07/2005 | A | Seton Hall | W | 3 | 0 | 15-0 | 5-0 | 90 | South Orange, N.J. | Walsh Gymnasium | Conf | |
| 10/08/2005 | A | Long Island | W | 3 | 1 | 16-0 | 5-0 | 122 | Long Island, N.Y. | Schwartz Center | ||
| 10/11/2005 | A | Xavier | W | 3 | 1 | 17-0 | 5-0 | 236 | Cincinnati, Ohio | Cintas Center | ||
| 10/16/2005 | A | Cincinnati | W | 3 | 1 | 18-0 | 6-0 | 551 | Cincinnati, Ohio | Fifth Third Arena | Conf | |
| 10/22/2005 | H | Pittsburgh | W | 3 | 1 | 19-0 | 7-0 | 866 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/23/2005 | H | West Virginia | W | 3 | 0 | 20-0 | 8-0 | 947 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/29/2005 | A | 7 | Notre Dame | L | 1 | 3 | 20-1 | 8-1 | 2,597 | South Bend, Ind. | Joyce Center | Conf |
| 10/30/2005 | A | DePaul | W | 3 | 0 | 21-1 | 9-1 | 301 | Chicago, Ill. | DePaul Athletic Center | Conf | |
| 11/04/2005 | A | Georgetown | W | 3 | 1 | 22-1 | 10-1 | 211 | Washington, D.C. | McDonough Arena | Conf | |
| 11/06/2005 | A | South Florida | W | 3 | 1 | 23-1 | 11-1 | 208 | Tampa, Fla. | The Corral | Conf | |
| 11/12/2005 | H | Marquette | W | 3 | 1 | 24-1 | 12-1 | 878 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/13/2005 | Syracuse | W | 3 | 1 | 25-1 | 13-1 | Conf | |||||
| 11/13/2005 | H | Syracuse (Exhibition) | W | 3 | 1 | Louisville, Ky. | ||||||
| 11/18/2005 | H | Marquette | W | 3 | 1 | 26-1 | 13-1 | 1,217 | Louisville, Ky. | Kentucky International Convention Center | CT | |
| 11/19/2005 | H | Syracuse | W | 3 | 1 | 27-1 | 13-1 | 1,156 | Louisville, Ky. | Kentucky International Convention Center | CT | |
| 11/20/2005 | H | 8 | Notre Dame | L | 2 | 3 | 27-2 | 13-1 | 1,954 | Louisville, Ky. | Kentucky International Convention Center | CT |
| 11/25/2005 | A | Georgia | W | 3 | 0 | 28-2 | 13-1 | 335 | South Bend, Ind. | Joyce Center | ||
| 11/26/2005 | A | Rice | W | 3 | 0 | 29-2 | 13-1 | 235 | South Bend, Ind. | Joyce Center | ||
| 12/02/2005 | H | Western Kentucky | W | 3 | 1 | 30-2 | 13-1 | 2,495 | Louisville, Ky. | Louisville Gardens | NCAA 1st Round | |
| 12/03/2005 | H | Maryland | W | 3 | 0 | 31-2 | 13-1 | 1,259 | Louisville, Ky. | Louisville Gardens | NCAA 2nd Round | |
| 12/09/2005 | A | 8 | Florida | L | 0 | 3 | 31-3 | 13-1 | 14,481 | Omaha, Neb. | Qwest Center Omaha | NCAA Regional Semifinal |