Head Coach: Leonid Yelin Record: 25-7 (13-1 Big East)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/25/2006 | H | Jacksonville State | L | 2 | 3 | 0-1 | 0-0 | 907 | Louisville, Ky. | Cardinal Arena | ||
| 08/26/2006 | H | Jacksonville | W | 3 | 0 | 1-1 | 0-0 | 361 | Louisville, Ky. | Cardinal Arena | ||
| 08/26/2006 | H | Missouri-Kansas City | W | 3 | 0 | 2-1 | 0-0 | 548 | Louisville, Ky. | Cardinal Arena | ||
| 09/01/2006 | H | Dayton | W | 3 | 1 | 3-1 | 0-0 | 682 | Louisville, Ky. | Cardinal Arena | ||
| 09/02/2006 | H | 18 | Arizona | L | 1 | 3 | 3-2 | 0-0 | 814 | Louisville, Ky. | Cardinal Arena | |
| 09/02/2006 | H | Tennessee Tech | W | 3 | 0 | 4-2 | 0-0 | 511 | Louisville, Ky. | Cardinal Arena | ||
| 09/08/2006 | A | Nebraska | L | 0 | 3 | 4-3 | 0-0 | 4,187 | Lincoln, Neb. | NU Coliseum | ||
| 09/09/2006 | N | Minnesota | W | 3 | 1 | 5-3 | 0-0 | Lincoln, Neb. | NU Coliseum | |||
| 09/10/2006 | N | Cal Poly | L | 2 | 3 | 5-4 | 0-0 | Lincoln, Neb. | NU Coliseum | |||
| 09/15/2006 | H | Wisconsin-Milwaukee | W | 3 | 0 | 6-4 | 0-0 | 769 | Louisville, Ky. | Cardinal Arena | ||
| 09/19/2006 | A | 17 | Tennessee | L | 1 | 3 | 6-5 | 0-0 | 251 | Knoxville, Tenn. | Stokely Athletic Center | |
| 09/22/2006 | A | Syracuse | W | 3 | 1 | 7-5 | 1-0 | Syracuse, N.Y. | Manley Field House | Conf | ||
| 09/24/2006 | A | Marquette | W | 3 | 1 | 8-5 | 2-0 | 1,076 | Milwaukee, Wis. | Al McGuire Center | Conf | |
| 09/29/2006 | A | St. John's | L | 0 | 3 | 8-6 | 2-1 | 239 | Queens, N.Y. | Carnesecca Arena | Conf | |
| 10/01/2006 | A | Connecticut | W | 3 | 1 | 9-6 | 3-1 | 236 | Storrs, Conn. | Gampel Pavilion | Conf | |
| 10/07/2006 | H | Rutgers | W | 3 | 0 | 10-6 | 4-1 | 407 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/08/2006 | H | Villanova | W | 3 | 0 | 11-6 | 5-1 | 638 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/11/2006 | H | Xavier | W | 3 | 1 | 12-6 | 5-1 | 572 | Louisville, Ky. | Cardinal Arena | ||
| 10/14/2006 | H | Cincinnati | W | 3 | 0 | 13-6 | 6-1 | 496 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/22/2006 | H | Seton Hall | W | 3 | 0 | 14-6 | 7-1 | 701 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/28/2006 | H | DePaul | W | 3 | 0 | 15-6 | 8-1 | 732 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/29/2006 | H | Notre Dame | W | 3 | 0 | 16-6 | 9-1 | 852 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/04/2006 | A | West Virginia | W | 3 | 1 | 17-6 | 10-1 | 85 | Morgantown, W.Va. | WVU Coliseum | Conf | |
| 11/05/2006 | A | Pittsburgh | W | 3 | 1 | 18-6 | 11-1 | 257 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 11/11/2006 | H | South Florida | W | 3 | 0 | 19-6 | 12-1 | 813 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/12/2006 | H | Georgetown | W | 3 | 0 | 20-6 | 13-1 | 794 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/17/2006 | N | 7 | Connecticut | W | 3 | 1 | 21-6 | 13-1 | Cincinnati, Ohio | Fifth Third Arena | CT | |
| 11/18/2006 | N | 6 | Marquette | W | 3 | 2 | 22-6 | 13-1 | Cincinnati, Ohio | Fifth Third Arena | CT | |
| 11/19/2006 | N | 5 | Notre Dame | W | 3 | 2 | 23-6 | 13-1 | 236 | Cincinnati, Ohio | Fifth Third Arena | CT |
| 11/24/2006 | H | Marshall | W | 3 | 0 | 24-6 | 13-1 | 798 | Louisville, Ky. | Cardinal Arena | ||
| 11/25/2006 | H | 18 | Ohio | W | 3 | 1 | 25-6 | 13-1 | 697 | Louisville, Ky. | Cardinal Arena | |
| 12/01/2006 | N | Middle Tennessee | L | 2 | 3 | 25-7 | 13-1 | Louisville, Ky. | Kentucky International Convention Center | NCAA 1st Round |