Head Coach: Leonid Yelin Record: 22-8 (13-1 Big East)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/24/2007 | H | Memphis | W | 3 | 1 | 1-0 | 0-0 | 927 | Louisville, Ky. | Cardinal Arena | ||
| 08/25/2007 | H | Coastal Carolina | W | 3 | 0 | 2-0 | 0-0 | 531 | Louisville, Ky. | Cardinal Arena | ||
| 08/25/2007 | H | Tennessee Tech | W | 3 | 1 | 3-0 | 0-0 | 879 | Louisville, Ky. | Cardinal Arena | ||
| 08/31/2007 | N | 5 | UCLA | L | 0 | 3 | 3-1 | 0-0 | Honolulu, Hawaii | Stan Sheriff Center | ||
| 09/01/2007 | N | 25 | Kansas State | L | 0 | 3 | 3-2 | 0-0 | 75 | Honolulu, Hawaii | Stan Sheriff Center | |
| 09/02/2007 | A | 16 | Hawaii | L | 1 | 3 | 3-3 | 0-0 | 6,083 | Honolulu, Hawaii | Stan Sheriff Center | |
| 09/07/2007 | N | New Mexico State | L | 2 | 3 | 3-4 | 0-0 | Lincoln, Neb. | NU Coliseum | |||
| 09/08/2007 | N | Duke | W | 3 | 2 | 4-4 | 0-0 | Lincoln, Neb. | NU Coliseum | |||
| 09/15/2007 | H | Eastern Kentucky | W | 3 | 0 | 5-4 | 0-0 | 847 | Louisville, Ky. | Cardinal Arena | ||
| 09/21/2007 | A | South Florida | W | 3 | 0 | 6-4 | 1-0 | 767 | Tampa, Fla. | The Corral | Conf | |
| 09/23/2007 | A | Georgetown | W | 3 | 0 | 7-4 | 2-0 | 67 | Washington, D.C. | McDonough Arena | Conf | |
| 09/29/2007 | H | Syracuse | W | 3 | 0 | 8-4 | 3-0 | 754 | Louisville, Ky. | Cardinal Arena | Conf | |
| 09/30/2007 | H | Marquette | W | 3 | 1 | 9-4 | 4-0 | 839 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/06/2007 | H | 18 | St. John's | W | 3 | 0 | 10-4 | 5-0 | 927 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/07/2007 | H | Connecticut | W | 3 | 0 | 11-4 | 6-0 | 903 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/13/2007 | A | Seton Hall | W | 3 | 0 | 12-4 | 7-0 | 44 | South Orange, N.J. | Walsh Gymnasium | Conf | |
| 10/14/2007 | A | Villanova | W | 3 | 1 | 13-4 | 8-0 | 163 | Philadelphia, Pa. | Jake Nevin Field House | Conf | |
| 10/16/2007 | H | Tennessee | W | 3 | 1 | 14-4 | 8-0 | 857 | Louisville, Ky. | Cardinal Arena | ||
| 10/20/2007 | H | Cincinnati | W | 3 | 1 | 15-4 | 9-0 | 854 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/28/2007 | A | Rutgers | W | 3 | 0 | 16-4 | 10-0 | 171 | Piscataway, N.J. | College Avenue Gym | Conf | |
| 10/31/2007 | A | Morehead State | W | 3 | 0 | 17-4 | 10-0 | 903 | Morehead, Ky. | Wetherby Gym | ||
| 11/02/2007 | H | West Virginia | W | 3 | 0 | 18-4 | 11-0 | 916 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/04/2007 | H | Pittsburgh | W | 3 | 1 | 19-4 | 12-0 | 899 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/09/2007 | A | DePaul | W | 3 | 0 | 20-4 | 13-0 | 388 | Chicago, Ill. | McGrath-Phillips Arena | Conf | |
| 11/11/2007 | A | Notre Dame | L | 1 | 3 | 20-5 | 13-1 | 1,511 | South Bend, Ind. | Joyce Center | Conf | |
| 11/16/2007 | N | Syracuse | W | 3 | 0 | 21-5 | 13-1 | 250 | Milwaukee, Wis. | Al McGuire Center | CT | |
| 11/17/2007 | N | Notre Dame | W | 3 | 0 | 22-5 | 13-1 | 350 | Milwaukee, Wis. | Al McGuire Center | CT | |
| 11/18/2007 | N | 20 | St. John's | L | 0 | 3 | 22-6 | 13-1 | 250 | Milwaukee, Wis. | Al McGuire Center | CT |
| 11/24/2007 | A | 19 | Ohio | L | 2 | 3 | 22-7 | 13-1 | 1,554 | Athens, Ohio | Convocation Center | |
| 11/30/2007 | H | Middle Tennessee | L | 2 | 3 | 22-8 | 13-1 | Louisville, Ky. | Kentucky International Convention Center | NCAA 1st Round |