Head Coach: Leonid Yelin Record: 19-11 (11-3 Big East)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/30/2008 | H | Indiana State | W | 3 | 0 | 1-0 | 0-0 | 914 | Louisville, Ky. | Cardinal Arena | |
| 09/05/2008 | N | Valparaiso | L | 2 | 3 | 1-1 | 0-0 | 109 | Bloomington, Ind. | Assembly Hall | |
| 09/05/2008 | N | Wake Forest | W | 3 | 1 | 2-1 | 0-0 | Bloomington, Ind. | Assembly Hall | ||
| 09/06/2008 | A | Indiana | L | 2 | 3 | 2-2 | 0-0 | 516 | Bloomington, Ind. | Assembly Hall | |
| 09/12/2008 | N | Illinois State | L | 2 | 3 | 2-3 | 0-0 | 306 | Chicago, Ill. | Mother McAuley Arena | |
| 09/13/2008 | A | Penn State | L | 0 | 3 | 2-4 | 0-0 | 450 | Chicago, Ill. | Mother McAuley Arena | |
| 09/13/2008 | N | Illinois-Chicago | W | 3 | 1 | 3-4 | 0-0 | 210 | Chicago, Ill. | Mother McAuley Arena | |
| 09/19/2008 | H | Miami, Ohio | W | 3 | 2 | 4-4 | 0-0 | Dayton, Ohio | Frericks Center | ||
| 09/20/2008 | A | Dayton | L | 2 | 3 | 4-5 | 0-0 | 595 | Dayton, Ohio | Frericks Center | |
| 09/20/2008 | N | Purdue | L | 0 | 3 | 4-6 | 0-0 | Dayton, Ohio | Frericks Center | ||
| 09/26/2008 | A | Connecticut | W | 3 | 1 | 5-6 | 1-0 | 338 | Storrs, Conn. | Gampel Pavilion | Conf |
| 09/28/2008 | A | St. John's | L | 2 | 3 | 5-7 | 1-1 | 175 | Jamaica, N.Y. | Taffner Field House | Conf |
| 10/04/2008 | H | Notre Dame | L | 0 | 3 | 5-8 | 1-2 | 899 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/05/2008 | H | DePaul | W | 3 | 1 | 6-8 | 2-2 | 841 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/08/2008 | A | Tennessee | L | 1 | 3 | 6-9 | 2-2 | 303 | Knoxville, Tenn. | Thompson-Boling Arena | |
| 10/11/2008 | H | Villanova | W | 3 | 1 | 7-9 | 3-2 | 722 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/12/2008 | H | Seton Hall | W | 3 | 1 | 8-9 | 4-2 | 794 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/18/2008 | A | Cincinnati | L | 1 | 3 | 8-10 | 4-3 | 371 | Cincinnati, Ohio | Fifth Third Arena | Conf |
| 10/24/2008 | A | Marquette | W | 3 | 0 | 9-10 | 5-3 | 405 | Milwaukee, Wis. | Al McGuire Center | Conf |
| 10/26/2008 | A | Syracuse | W | 3 | 1 | 10-10 | 6-3 | 120 | Syracuse, N.Y. | Women's Building | Conf |
| 10/31/2008 | H | Georgetown | W | 3 | 0 | 11-10 | 7-3 | 1,095 | Louisville, Ky. | Hoops Athletic Center | Conf |
| 11/02/2008 | H | South Florida | W | 3 | 0 | 12-10 | 8-3 | 994 | Louisville, Ky. | Cardinal Arena | Conf |
| 11/07/2008 | A | Pittsburgh | W | 3 | 0 | 13-10 | 9-3 | 1,522 | Pittsburgh, Pa. | Fitzgerald Field House | Conf |
| 11/09/2008 | A | West Virginia | W | 3 | 0 | 14-10 | 10-3 | 250 | Morgantown, W.Va. | WVU Coliseum | Conf |
| 11/15/2008 | H | Rutgers | W | 3 | 0 | 15-10 | 11-3 | 1,011 | Louisville, Ky. | Cardinal Arena | Conf |
| 11/21/2008 | N | Syracuse | W | 3 | 0 | 16-10 | 11-3 | Pittsburgh, Pa. | Fitzgerald Field House | ||
| 11/22/2008 | N | Pittsburgh | W | 3 | 1 | 17-10 | 11-3 | Pittsburgh, Pa. | Fitzgerald Field House | ||
| 11/23/2008 | N | Notre Dame | W | 3 | 1 | 18-10 | 11-3 | 373 | Pittsburgh, Pa. | Fitzgerald Field House | |
| 11/29/2008 | H | Tennessee Tech | W | 3 | 0 | 19-10 | 11-3 | 997 | Louisville, Ky. | Cardinal Arena | |
| 12/05/2008 | N | Purdue | L | 2 | 3 | 19-11 | 11-3 | West Lafayette, Ind. | NCAA 1st Round |