Head Coach: Leonid Yelin Record: 21-11 (10-4 Big East)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/28/2009 | H | Arizona | L | 0 | 3 | 0-1 | 0-0 | Louisville, Ky. | Cardinal Arena | ||
| 08/29/2009 | H | Belmont | W | 3 | 1 | 1-1 | 0-0 | Louisville, Ky. | Cardinal Arena | ||
| 08/30/2009 | H | Wichita State | L | 1 | 3 | 1-2 | 0-0 | Louisville, Ky. | Cardinal Arena | ||
| 09/04/2009 | N | Southern Illinois-Edwardsville | W | 3 | 0 | 2-2 | 0-0 | Muncie, Ind. | Worthen Arena | ||
| 09/05/2009 | A | Ball State | W | 3 | 1 | 3-2 | 0-0 | 388 | Muncie, Ind. | Worthen Arena | |
| 09/05/2009 | N | IPFW | W | 3 | 1 | 4-2 | 0-0 | Muncie, Ind. | Worthen Arena | ||
| 09/11/2009 | H | Tennessee Tech | W | 3 | 1 | 5-2 | 0-0 | 899 | Louisville, Ky. | Cardinal Arena | |
| 09/12/2009 | H | Toledo | L | 2 | 3 | 5-3 | 0-0 | 574 | Louisville, Ky. | Cardinal Arena | |
| 09/12/2009 | H | Liberty | W | 3 | 1 | 6-3 | 0-0 | 674 | Louisville, Ky. | Cardinal Arena | |
| 09/16/2009 | H | Kentucky | W | 3 | 2 | 7-3 | 0-0 | 1,270 | Louisville, Ky. | Cardinal Arena | |
| 09/18/2009 | N | Illinois | L | 1 | 3 | 7-4 | 0-0 | West Lafayette, Ind. | Holloway Gymnasium | ||
| 09/19/2009 | A | Purdue | L | 0 | 3 | 7-5 | 0-0 | 2,560 | West Lafayette, Ind. | Holloway Gymnasium | |
| 09/27/2009 | A | Villanova | W | 3 | 1 | 8-5 | 1-0 | 211 | Philadelphia, Pa. | Jake Nevin Field House | Conf |
| 09/30/2009 | H | Tennessee | L | 2 | 3 | 8-6 | 1-0 | 812 | Louisville, Ky. | Cardinal Arena | |
| 10/03/2009 | H | West Virginia | W | 3 | 0 | 9-6 | 2-0 | 743 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/04/2009 | H | Pittsburgh | L | 2 | 3 | 9-7 | 2-1 | 694 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/09/2009 | A | DePaul | W | 3 | 0 | 10-7 | 3-1 | 222 | Chicago, Ill. | McGrath-Phillips Arena | Conf |
| 10/11/2009 | A | Notre Dame | L | 1 | 3 | 10-8 | 3-2 | 1,746 | South Bend, Ind. | Joyce Center | Conf |
| 10/17/2009 | A | Seton Hall | W | 3 | 1 | 11-8 | 4-2 | 115 | South Orange, N.J. | Walsh Gymnasium | Conf |
| 10/18/2009 | A | Rutgers | W | 3 | 0 | 12-8 | 5-2 | 89 | Piscataway, N.J. | College Avenue Gym | Conf |
| 10/23/2009 | A | Cincinnati | L | 0 | 3 | 12-9 | 5-3 | 711 | Cincinnati, Ohio | Fifth Third Arena | Conf |
| 10/30/2009 | H | Syracuse | W | 3 | 1 | 13-9 | 6-3 | 837 | Louisville, Ky. | Cardinal Arena | Conf |
| 11/01/2009 | H | Marquette | W | 3 | 0 | 14-9 | 7-3 | 817 | Louisville, Ky. | Cardinal Arena | Conf |
| 11/06/2009 | A | South Florida | L | 0 | 3 | 14-10 | 7-4 | 979 | Tampa, Fla. | The Corral | Conf |
| 11/08/2009 | A | Georgetown | W | 3 | 1 | 15-10 | 8-4 | 208 | Washington, D.C. | McDonough Arena | Conf |
| 11/13/2009 | H | St. John's | W | 3 | 0 | 16-10 | 9-4 | 924 | Louisville, Ky. | Kentucky International Convention Center | Conf |
| 11/15/2009 | H | Connecticut | W | 3 | 1 | 17-10 | 10-4 | 910 | Louisville, Ky. | Kentucky International Convention Center | Conf |
| 11/20/2009 | H | Syracuse | W | 3 | 0 | 18-10 | 10-4 | 818 | Louisville, Ky. | Kentucky International Convention Center | |
| 11/21/2009 | H | Notre Dame | W | 3 | 2 | 19-10 | 10-4 | 757 | Louisville, Ky. | Kentucky International Convention Center | |
| 11/22/2009 | H | Cincinnati | W | 3 | 1 | 20-10 | 10-4 | 718 | Louisville, Ky. | Kentucky International Convention Center | |
| 11/28/2009 | H | Jacksonville State | W | 3 | 1 | 21-10 | 10-4 | 913 | Louisville, Ky. | Cardinal Arena | |
| 12/04/2009 | N | Minnesota | L | 1 | 3 | 21-11 | 10-4 | Knoxville, Tenn. | Thompson-Boling Arena | NCAA 1st Round |