Head Coach: Leonid Yelin Record: 23-8 (12-2 Big East)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/27/2010 | H | North Dakota State | W | 3 | 1 | 1-0 | 0-0 | 934 | Louisville, Ky. | Cardinal Arena | ||
| 08/29/2010 | H | Ohio | W | 3 | 2 | 2-0 | 0-0 | 912 | Louisville, Ky. | Cardinal Arena | ||
| 09/01/2010 | A | 16 | Kentucky | L | 2 | 3 | 2-1 | 0-0 | 2,178 | Lexington, Ky. | Memorial Coliseum | |
| 09/03/2010 | A | 24 | Arizona | L | 2 | 3 | 2-2 | 0-0 | 770 | Tucson, Ariz. | McKale Center | |
| 09/03/2010 | N | Cal State Bakersfield | W | 3 | 1 | 3-2 | 0-0 | 115 | Tucson, Ariz. | McKale Center | ||
| 09/04/2010 | N | Butler | W | 3 | 1 | 4-2 | 0-0 | 64 | Tucson, Ariz. | McKale Center | ||
| 09/10/2010 | A | Wright State | W | 3 | 0 | 5-2 | 0-0 | 490 | Dayton, Ohio | C.J. McLin Gymnasium | ||
| 09/17/2010 | H | Purdue | L | 1 | 3 | 5-3 | 0-0 | 1,027 | Louisville, Ky. | Cardinal Arena | ||
| 09/18/2010 | H | 5 | Illinois | L | 1 | 3 | 5-4 | 0-0 | 912 | Louisville, Ky. | Cardinal Arena | |
| 09/25/2010 | H | Rutgers | W | 3 | 0 | 6-4 | 1-0 | 797 | Louisville, Ky. | Cardinal Arena | Conf | |
| 09/26/2010 | H | Seton Hall | L | 2 | 3 | 6-5 | 1-1 | 784 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/01/2010 | A | Connecticut | W | 3 | 0 | 7-5 | 2-1 | 104 | Storrs, Conn. | Gampel Pavilion | Conf | |
| 10/03/2010 | A | St. John's | W | 3 | 0 | 8-5 | 3-1 | 307 | Jamaica, N.Y. | Carnesecca Arena | Conf | |
| 10/09/2010 | H | Notre Dame | W | 3 | 1 | 9-5 | 4-1 | 579 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/10/2010 | H | DePaul | W | 3 | 0 | 10-5 | 5-1 | 738 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/16/2010 | H | 21 | Cincinnati | W | 3 | 2 | 11-5 | 6-1 | 877 | Louisville, Ky. | Cardinal Arena | Conf |
| 10/20/2010 | H | Lipscomb | W | 3 | 0 | 12-5 | 6-1 | 601 | Louisville, Ky. | Cardinal Arena | ||
| 10/22/2010 | H | Georgetown | W | 3 | 1 | 13-5 | 7-1 | 844 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/24/2010 | H | South Florida | W | 3 | 2 | 14-5 | 8-1 | 794 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/27/2010 | A | 22 | Tennessee | L | 1 | 3 | 14-6 | 8-1 | 502 | Knoxville, Tenn. | Thompson-Boling Arena | |
| 10/29/2010 | H | Villanova | W | 3 | 2 | 15-6 | 9-1 | 921 | Louisville, Ky. | Cardinal Arena | Conf | |
| 11/06/2010 | A | Pittsburgh | W | 3 | 1 | 16-6 | 10-1 | 537 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 11/07/2010 | A | West Virginia | W | 3 | 0 | 17-6 | 11-1 | 345 | Morgantown, W.Va. | WVU Coliseum | Conf | |
| 11/12/2010 | A | Marquette | L | 2 | 3 | 17-7 | 11-2 | 925 | Milwaukee, Wis. | Al McGuire Center | Conf | |
| 11/14/2010 | A | Syracuse | W | 3 | 1 | 18-7 | 12-2 | 312 | Syracuse, N.Y. | Women's Building | Conf | |
| 11/19/2010 | N | Seton Hall | W | 3 | 1 | 19-7 | 12-2 | Pittsburgh, Pa. | Fitzgerald Field House | |||
| 11/20/2010 | N | Marquette | W | 3 | 1 | 20-7 | 12-2 | 364 | Pittsburgh, Pa. | Fitzgerald Field House | ||
| 11/21/2010 | N | Cincinnati | W | 3 | 0 | 21-7 | 12-2 | 243 | Pittsburgh, Pa. | Fitzgerald Field House | ||
| 11/27/2010 | H | Austin Peay | W | 3 | 1 | 22-7 | 12-2 | 775 | Louisville, Ky. | Cardinal Arena | ||
| 12/03/2010 | N | Middle Tennessee | W | 3 | 0 | 23-7 | 12-2 | West Lafayette, Ind. | Holloway Gymnasium | NCAA 1st Round | ||
| 12/04/2010 | N | Purdue | L | 1 | 3 | 23-8 | 12-2 | 1,374 | West Lafayette, Ind. | Holloway Gymnasium | NCAA 2nd Round |