Head Coach: Dani Busboom Kelly Record: 24-7 (18-2 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/25/2017 | A | 7 | Wisconsin | L | 0 | 3 | 0-1 | 0-0 | 6,012 | Madison, Wis. | UW Field House | ACC/Big Ten Challenge | |
| 08/26/2017 | N | 4 | Minnesota | L | 1 | 3 | 0-2 | 0-0 | 6,012 | Madison, Wis. | UW Field House | ACC/Big Ten Challenge | |
| 09/01/2017 | H | 24 | Western Kentucky | W | 3 | 1 | 1-2 | 0-0 | 1,025 | Louisville, Ky. | Cardinal Arena | Cardinal Classic | |
| 09/02/2017 | H | Kent State | W | 3 | 0 | 2-2 | 0-0 | 814 | Louisville, Ky. | Cardinal Arena | Cardinal Classic | ||
| 09/02/2017 | H | Illinois | L | 0 | 3 | 2-3 | 0-0 | 932 | Louisville, Ky. | Cardinal Arena | Cardinal Classic | ||
| 09/08/2017 | N | UC Irvine | W | 3 | 0 | 3-3 | 0-0 | 466 | Las Vegas, Nev. | Cox Pavilion | UNLV Challenge | ||
| 09/08/2017 | N | Weber State | W | 3 | 1 | 4-3 | 0-0 | Las Vegas, Nev. | Cox Pavilion | UNLV Challenge | |||
| 09/09/2017 | A | Nevada-Las Vegas | W | 3 | 0 | 5-3 | 0-0 | Las Vegas, Nev. | Cox Pavilion | UNLV Challenge | |||
| 09/15/2017 | A | 12 | Kentucky | L | 0 | 3 | 5-4 | 0-0 | 3,402 | Lexington, Ky. | Memorial Coliseum | ||
| 09/17/2017 | H | Kennesaw State | W | 3 | 0 | 6-4 | 0-0 | 737 | Louisville, Ky. | Cardinal Arena | |||
| 09/22/2017 | H | Notre Dame | W | 3 | 2 | 7-4 | 1-0 | 1,032 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 09/24/2017 | A | North Carolina | L | 2 | 3 | 7-5 | 1-1 | 724 | Chapel Hill, N.C. | Carmichael Arena | Conf | ||
| 09/29/2017 | H | 21 | Florida State | W | 3 | 0 | 8-5 | 2-1 | 1,076 | Louisville, Ky. | Cardinal Arena | Conf | |
| 10/01/2017 | H | Miami, Fla. | W | 3 | 0 | 9-5 | 3-1 | 996 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/06/2017 | A | Virginia Tech | W | 3 | 1 | 10-5 | 4-1 | 2,361 | Blacksburg, Va. | Cassell Coliseum | Conf | ||
| 10/08/2017 | A | Virginia | W | 3 | 1 | 11-5 | 5-1 | 529 | Charlottesville, Va. | Memorial Gymnasium | Conf | ||
| 10/13/2017 | H | Clemson | W | 3 | 0 | 12-5 | 6-1 | 914 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/15/2017 | H | Georgia Tech | W | 3 | 0 | 13-5 | 7-1 | 1,038 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/20/2017 | A | Miami, Fla. | L | 1 | 3 | 13-6 | 7-2 | 770 | Coral Gables, Fla. | Knight Gym | Conf | ||
| 10/22/2017 | A | Florida State | W | 3 | 0 | 14-6 | 8-2 | 925 | Tallahassee, Fla. | Tully Gymnasium | Conf | ||
| 10/25/2017 | A | Notre Dame | W | 3 | 2 | 15-6 | 9-2 | 573 | South Bend, Ind. | Purcell Pavilion | Conf | ||
| 10/27/2017 | H | Pittsburgh | W | 3 | 2 | 16-6 | 10-2 | 889 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/03/2017 | A | Wake Forest | W | 3 | 0 | 17-6 | 11-2 | 247 | Winston-Salem, N.C. | LJVM Coliseum | Conf | ||
| 11/05/2017 | A | Duke | W | 3 | 2 | 18-6 | 12-2 | 987 | Durham, N.C. | Cameron Indoor Stadium | Conf | ||
| 11/10/2017 | H | Virginia | W | 3 | 0 | 19-6 | 13-2 | 922 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/12/2017 | H | Virginia Tech | W | 3 | 0 | 20-6 | 14-2 | 909 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/17/2017 | H | North Carolina State | W | 3 | 0 | 21-6 | 15-2 | 965 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/19/2017 | H | North Carolina | W | 3 | 2 | 22-6 | 16-2 | 1,077 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/22/2017 | A | Boston College | W | 3 | 1 | 23-6 | 17-2 | 187 | Chestnut Hill, Mass. | Power Gym | Conf | ||
| 11/24/2017 | A | Syracuse | W | 3 | 2 | 24-6 | 18-2 | 329 | Syracuse, N.Y. | Women's Building | Conf | ||
| 12/01/2017 | N | Northern Iowa | L | 0 | 3 | 24-7 | 18-2 | Minneapolis, Minn. | Maturi Pavilion | NCAA 1st Round |