Head Coach: Dani Busboom Kelly Record: 22-9 (14-4 ACC)
| Date | Site | Opp Rk | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/24/2018 | H | Tennessee-Martin | W | 3 | 0 | 1-0 | 0-0 | 566 | Louisville, Ky. | Cardinal Arena | Cardinal Classic | ||
| 08/24/2018 | H | Southern Illinois | W | 3 | 0 | 2-0 | 0-0 | 733 | Louisville, Ky. | Cardinal Arena | Cardinal Classic | ||
| 08/25/2018 | H | IUPUI | W | 3 | 0 | 3-0 | 0-0 | 748 | Louisville, Ky. | Cardinal Arena | Cardinal Classic | ||
| 08/31/2018 | N | Central Florida | W | 3 | 0 | 4-0 | 0-0 | Gainesville, Fla. | Exactech Arena | University of Florida Tournament | |||
| 09/01/2018 | A | 4 | Florida | L | 1 | 3 | 4-1 | 0-0 | 4,801 | Gainesville, Fla. | Exactech Arena | University of Florida Tournament | |
| 09/02/2018 | N | 7 | Southern California | L | 0 | 3 | 4-2 | 0-0 | Gainesville, Fla. | Exactech Arena | University of Florida Tournament | ||
| 09/07/2018 | N | Lipscomb | W | 3 | 1 | 5-2 | 0-0 | 1,582 | West Lafayette, Ind. | Holloway Gymnasium | Purdue Tournament | ||
| 09/07/2018 | N | Xavier | W | 3 | 0 | 6-2 | 0-0 | West Lafayette, Ind. | Holloway Gymnasium | Purdue Tournament | |||
| 09/08/2018 | A | 19 | Purdue | L | 2 | 3 | 6-3 | 0-0 | 2,415 | West Lafayette, Ind. | Holloway Gymnasium | Purdue Tournament | |
| 09/14/2018 | H | 20 | Kentucky | L | 0 | 3 | 6-4 | 0-0 | 1,083 | Louisville, Ky. | Cardinal Arena | ||
| 09/15/2018 | H | Chattanooga | W | 3 | 0 | 7-4 | 0-0 | 758 | Louisville, Ky. | Cardinal Arena | |||
| 09/21/2018 | A | North Carolina State | W | 3 | 1 | 8-4 | 1-0 | 1,618 | Raleigh, N.C. | Reynolds Coliseum | Conf | ||
| 09/23/2018 | A | North Carolina | W | 3 | 2 | 9-4 | 2-0 | 1,460 | Chapel Hill, N.C. | Carmichael Arena | Conf | ||
| 09/28/2018 | A | Georgia Tech | W | 3 | 0 | 10-4 | 3-0 | 907 | Atlanta, Ga. | O'Keefe Gym | Conf | ||
| 09/30/2018 | A | Clemson | W | 3 | 2 | 11-4 | 4-0 | 1,347 | Clemson, S.C. | Jervey Gymnasium | Conf | ||
| 10/05/2018 | H | Duke | W | 3 | 0 | 12-4 | 5-0 | 832 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/07/2018 | H | Wake Forest | W | 3 | 0 | 13-4 | 6-0 | 878 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/10/2018 | H | Notre Dame | W | 3 | 2 | 14-4 | 7-0 | 513 | Louisville, Ky. | Sacred Heart Academy | Conf | ||
| 10/12/2018 | H | Virginia Tech | W | 3 | 0 | 15-4 | 8-0 | 968 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/19/2018 | A | Virginia | W | 3 | 2 | 16-4 | 9-0 | 1,084 | Charlottesville, Va. | Memorial Gymnasium | Conf | ||
| 10/21/2018 | A | 6 | Pittsburgh | L | 1 | 3 | 16-5 | 9-1 | 2,152 | Pittsburgh, Pa. | Fitzgerald Field House | Conf | |
| 10/26/2018 | H | Boston College | W | 3 | 1 | 17-5 | 10-1 | 926 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 10/28/2018 | H | Syracuse | L | 2 | 3 | 17-6 | 10-2 | 808 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/02/2018 | H | Miami, Fla. | W | 3 | 1 | 18-6 | 11-2 | 1,027 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/04/2018 | H | Florida State | L | 1 | 3 | 18-7 | 11-3 | 1,085 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/09/2018 | A | Boston College | W | 3 | 1 | 19-7 | 12-3 | 309 | Chestnut Hill, Mass. | Power Gym | Conf | ||
| 11/11/2018 | A | Wake Forest | W | 3 | 0 | 20-7 | 13-3 | 471 | Winston-Salem, N.C. | Reynolds Gym | Conf | ||
| 11/16/2018 | A | Notre Dame | L | 2 | 3 | 20-8 | 13-4 | 1,265 | South Bend, Ind. | Purcell Pavilion | Conf | ||
| 11/23/2018 | H | Georgia Tech | W | 3 | 0 | 21-8 | 14-4 | 1,056 | Louisville, Ky. | Cardinal Arena | Conf | ||
| 11/30/2018 | N | Dayton | W | 3 | 0 | 22-8 | 14-4 | Champaign, Ill. | Huff Hall | NCAA 1st Round | |||
| 12/01/2018 | A | 3 | Illinois | L | 1 | 3 | 22-9 | 14-4 | 3,754 | Urbana-Champaign, Ill. | Huff Hall | NCAA 2nd Round |