Head Coach: Dan Meske Record: 26-7 (16-4 ACC)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | Arena | Event | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/29/2025 | H | Auburn | W | 3 | 0 | 1-0 | 0-0 | 1,007 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | |
| 08/31/2025 | H | Morehead State | W | 3 | 0 | 2-0 | 0-0 | 1,013 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | |
| 09/01/2025 | H | St. John's | W | 3 | 0 | 3-0 | 0-0 | 1,013 | Louisville, Ky. | L&N Federal Credit Union Arena | Cardinal Classic | |
| 09/07/2025 | H | Illinois | W | 3 | 1 | 4-0 | 0-0 | 6,290 | Louisville, Ky. | L&N Federal Credit Union Arena | ||
| 09/10/2025 | N | Texas | L | 2 | 3 | 4-1 | 0-0 | 4,296 | Fort Worth, Texas | Dickies Arena | Showdown at the Net | |
| 09/12/2025 | A | Creighton | W | 3 | 1 | 5-1 | 0-0 | 2,658 | Omaha, Neb. | D.J. Sokol Arena | ||
| 09/13/2025 | N | Northern Iowa | W | 3 | 1 | 6-1 | 0-0 | 2,158 | Omaha, Neb. | D.J. Sokol Arena | ||
| 09/14/2025 | N | Rice | W | 3 | 1 | 7-1 | 0-0 | Omaha, Neb. | D.J. Sokol Arena | |||
| 09/18/2025 | H | Kentucky | L | 2 | 3 | 7-2 | 0-0 | 10,787 | Louisville, Ky. | KFC Yum! Center | ||
| 09/22/2025 | H | Western Kentucky | W | 3 | 0 | 8-2 | 0-0 | 5,796 | Louisville, Ky. | L&N Federal Credit Union Arena | ||
| 09/26/2025 | H | Boston College | W | 3 | 0 | 9-2 | 1-0 | 1,015 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 09/28/2025 | H | Syracuse | W | 3 | 0 | 10-2 | 2-0 | 1,021 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/03/2025 | A | California | W | 3 | 0 | 11-2 | 3-0 | 1,335 | Berkeley, Calif. | Haas Pavilion | Conf | |
| 10/05/2025 | A | Stanford | W | 3 | 1 | 12-2 | 4-0 | 3,828 | Stanford, Calif. | Maples Pavilion | Conf | |
| 10/10/2025 | H | Virginia Tech | W | 3 | 0 | 13-2 | 5-0 | 1,053 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/12/2025 | H | Virginia | W | 3 | 1 | 14-2 | 6-0 | 1,037 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/17/2025 | H | Southern Methodist | L | 2 | 3 | 14-3 | 6-1 | 1,063 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/19/2025 | H | Pittsburgh | L | 2 | 3 | 14-4 | 6-2 | 1,039 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 10/24/2025 | A | Duke | W | 3 | 0 | 15-4 | 7-2 | 637 | Durham, N.C. | Cameron Indoor Stadium | Conf | |
| 10/26/2025 | A | North Carolina | W | 3 | 1 | 16-4 | 8-2 | 2,816 | Chapel Hill, N.C. | Carmichael Arena | Conf | |
| 10/29/2025 | A | Notre Dame | W | 3 | 0 | 17-4 | 9-2 | 927 | South Bend, Ind. | Purcell Pavilion at the Joyce Center | Conf | |
| 11/01/2025 | H | Notre Dame | W | 3 | 0 | 18-4 | 10-2 | 7,984 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 11/07/2025 | A | North Carolina State | W | 3 | 0 | 19-4 | 11-2 | 2,443 | Raleigh, N.C. | Reynolds Coliseum | Conf | |
| 11/09/2025 | A | Wake Forest | W | 3 | 1 | 20-4 | 12-2 | 837 | Winston-Salem, N.C. | Reynolds Gym | Conf | |
| 11/13/2025 | H | Florida State | W | 3 | 1 | 21-4 | 13-2 | 1,063 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 11/16/2025 | H | Miami, Fla. | W | 3 | 2 | 22-4 | 14-2 | 1,041 | Louisville, Ky. | L&N Federal Credit Union Arena | Conf | |
| 11/21/2025 | A | Georgia Tech | W | 3 | 1 | 23-4 | 15-2 | 1,200 | Atlanta, Ga. | O'Keefe Gym | Conf | |
| 11/23/2025 | A | Clemson | W | 3 | 0 | 24-4 | 16-2 | 1,500 | Clemson, S.C. | Jervey Gymnasium | Conf | |
| 11/26/2025 | A | Pittsburgh | L | 0 | 3 | 24-5 | 16-3 | 7,928 | Pittsburgh, Pa. | Petersen Events Center | Conf | |
| 11/29/2025 | H | Stanford | L | 2 | 3 | 24-6 | 16-4 | 1,063 | Louisville, Ky. | KFC Yum! Center | Conf | |
| 12/05/2025 | H | Loyola-Chicago | W | 3 | 0 | 25-6 | 16-4 | 1,181 | Louisville, Ky. | L&N Federal Credit Union Arena | NCAA Championship | NCAA 1st Round |
| 12/06/2025 | H | Marquette | W | 3 | 2 | 26-6 | 16-4 | 1,098 | Louisville, Ky. | L&N Federal Credit Union Arena | NCAA Championship | NCAA 2nd Round |
| 12/12/2025 | N | Texas A&M | L | 2 | 3 | 26-7 | 16-4 | Lincoln, Neb. | Bob Devaney Sports Center |